SUBSTANCE USE DISORDERS

This study compares two approaches to help people with both substance use and mental health disorders stay engaged in treatment and reduce overdose risk. About 208 participants will be randomly assigned to either a team-based program called MISSION or a peer specialist. Researche…

This study tests a program called Connections that uses a smartphone app and peer mentors to support people with HIV who also have substance use disorders. The goal is to help them keep their virus under control and attend their clinic appointments. About 433 participants from 8 …

This study tests whether a personalized program—including patient navigation, individual health benefits, and financial help—can reduce deaths from preventable causes like heart attacks, strokes, heavy drinking, and HIV in low-income adults aged 35–64. Researchers will track chan…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This study looks at whether a peer-led support program can help people living with HIV also get treatment for mental health or substance use problems. About 405 participants will be randomly assigned to either usual care or working with a peer case manager. The main goal is to se…

This study looks at whether a therapy called RRFT, which treats substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with both conditions will be randomly assigned to RRFT or usual care, and tracked for a year. The …

This study tests whether a special team that treats both severe infections and substance use disorders together can help hospitalized patients who inject drugs. The goal is to lower death rates and reduce repeat hospital visits. About 480 adults will either get this combined care…

This study tests a program called the Bridge Model that provides social support, volunteering, and job opportunities to help people who are homeless or low-income quit smoking and reduce substance use. About 250 participants in Ottawa and Toronto will be randomly assigned to rece…

This study aims to eliminate hepatitis C among people who use drugs in Paris, Marseille, Lyon, and Fort-de-France by offering free screening and immediate treatment. About 3,400 participants will be tested and treated at community centers, and they can also refer friends. The goa…

This trial tests a school program called PreVenture that uses personality traits to help teens avoid drugs and alcohol. Over 12,000 students in Canada will take part, with some schools using the program and others continuing standard lessons. The goal is to see if the program del…

This study tests a special type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks and then put on a performance. Res…

This study from Mayo Clinic tests a smartphone app that helps primary care doctors screen for substance use disorders and connect patients to treatment. Researchers will look at what helps or hinders using this digital tool in real clinics. About 60 adults who already have a prim…

This study was designed to test whether a non-invasive brain stimulation technique called continuous theta burst stimulation (cTBS) could reduce cravings in people with methamphetamine use disorder. Researchers planned to enroll 40 adults living in a residential treatment program…

This study looks at two different methods to help community hospitals start treating opioid use disorder. Researchers will compare a low-intensity approach to a high-intensity one. The goal is to see which method works better at getting patients to continue their medication for o…

This study tests whether a text message-based mental health and substance use screening program helps more pregnant and postpartum women attend treatment compared to standard in-person screening. About 10,470 women from MUSC clinics will participate by completing online questionn…

This study looks at how people's bodies react to stress in a pretend emergency room. Researchers will have 30 adults (20 who use meth and 10 healthy volunteers) do public speaking and math tasks while measuring stress hormones, heart rate, and blood pressure. The goal is to see i…

This study tests a new way to screen people with HIV for substance use disorders using an online patient portal, instead of only during clinic visits. The goal is to make screening easier and more accessible, especially for those who may not have regular appointments. About 900 a…

This study aimed to understand how a person's socioeconomic status (like income and education) affects their recovery from substance use disorder. Researchers planned to follow adults in early recovery for up to 3 years, measuring changes in social functioning, quality of life, a…

This study follows 120 people in group therapy for alcohol use disorder to see which patient traits—like mental health, drinking severity, personality, or thinking skills—lead to better outcomes. Researchers want to help doctors choose the right therapy for each person. The goal …

This study aimed to see if a brain training method called ZQLN could improve brain activity and thinking skills in people with cocaine use disorder. It planned to enroll adults aged 21 to 51 who had completed detox. However, the study was withdrawn before any participants were en…

This study tests whether telehealth programs can help people manage their alcohol use and improve well-being. About 300 adults with alcohol use disorder will join remotely via video or phone. They will be split into two groups: one gets a telehealth program, the other gets usual …

This study looked at whether combining patient questionnaires, staff training, and telemedicine could help people with HIV get better mental health and substance use care. It planned to include all adult HIV patients at five clinics in Alabama. The study was withdrawn before enro…

This study looks at whether counseling sessions done over video or phone can work for people with substance use disorder who are not currently getting treatment. About 50 adults from Michigan Medicine will try the program and fill out surveys to share their experience. The goal i…

This study looks at how to help primary care clinics screen more adults for substance use problems. It compares different support strategies like coaching, team learning, and financial rewards. 144 clinic staff from 48 practices will take part. The goal is to find the best way to…

This study looks at whether a special therapy called MIO-CPP, along with support from recovery specialists, can help mothers in treatment for substance use disorders and their young children (birth to 5 years). About 320 mother-child pairs will take part. The goal is to improve c…