SUBSTANCE USE DISORDERS

This pilot study tests a program called Yuva Sath, where trained peer counselors provide one-on-one sessions and weekly check-ins to young people (18-29) who inject drugs in India. The goal is to see if this support helps them stay in addiction treatment and use HIV prevention se…

This study tests a program called MISSION-CJ that helps people leaving jail who have both mental health and substance use disorders. The program connects them with peer support and community services to stay in treatment and avoid relapse. Researchers will track how well particip…

This study tests whether a single dose of psilocybin (5, 10, or 25 mg) combined with psychotherapy is safe and can reduce depression and substance use in veterans and first responders with treatment-resistant depression and substance use disorder. Over 14 weeks, 50 participants w…

This study tests whether using a mobile app called the Safe and Sound Protocol (SSP) can help adults who are in treatment for substance use and have a history of trauma. About 100 participants will either use the active SSP or a sham version for up to 5 hours over a week, alongsi…

This study tests whether daridorexant, a recently FDA-approved insomnia drug, can improve sleep quality and daytime alertness in smokers trying to quit. About 44 adult smokers who smoke at least 10 cigarettes daily will take the drug and be monitored for 3 weeks. The goal is to s…

This study tests a mobile app that teaches people with substance use disorders how addiction affects the brain. The goal is to see if this knowledge helps them stay in treatment and improve their recovery. Forty adults currently on medication for opioid or stimulant use will try …

This study looks at how kratom affects people who have used opioids in the past. Researchers will compare kratom to another substance and a placebo to see how the body processes it and what effects it has. The goal is to better understand kratom's safety and potential risks. Abou…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study looks at what happens to your brain and body when you briefly stop taking tirzepatide, a medication for blood sugar and appetite. Researchers will track changes in hunger, mood, sleep, and brain activity in 40 adults aged 18-70 who are already on the drug. Participants…

This study tests if a 12-week one-on-one support program is easy to complete and acceptable for people supporting a loved one who recently finished substance use treatment. About 18 participants will attend weekly telehealth sessions and complete surveys and interviews. The goal …

This study will test if a technology-based tool is helpful and easy to use for people living in supportive housing who also have substance use issues. About 25 residents and staff will try the tool, which includes videos and rewards, for two weeks. Researchers want to see if it i…