SUBSTANCE-RELATED DISORDERS
Clinical trials for SUBSTANCE-RELATED DISORDERS explained in plain language.
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New therapy aims to help teens battling addiction and anxiety
Disease control CompletedThis study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Disease control
Last updated Jun 27, 2026 13:06 UTC
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New therapy aims to curb Self-Harm in addiction
Disease control CompletedThis study tested whether a culturally adapted therapy called CMAP Plus is practical and acceptable for people with substance use disorder who also self-harm. The therapy combines problem-solving skills with motivational interviewing and was delivered weekly for 12 weeks. The tri…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: Pakistan Institute of Living and Learning • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Monthly shot vs. daily pills: new hope for opioid treatment in rural america?
Disease control CompletedThis study tested whether a once-monthly injection (XR-BUP) works as well as daily pills (SL-BUP) for treating opioid use disorder in rural settings. 140 adults with moderate to severe opioid use disorder took part. The goal was to see if the injection is practical and acceptable…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: PHASE3 • Sponsor: Yih-Ing Hser • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Peer coaches may help Justice-Involved youth cut drug use
Disease control CompletedThis pilot study tested whether paraprofessional coaches (with or without their own history of substance use) can help young adults aged 18-26 who have been involved with the justice system reduce their opioid and other drug use. The coaches used a combination of prize-based rewa…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: Chestnut Health Systems • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Mindfulness may keep women in addiction treatment longer
Disease control CompletedThis study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Peer power: new study tests buddy system for opioid recovery
Disease control CompletedThis study tested whether a trained peer recovery specialist could help low-income, minority individuals stick with their methadone treatment for opioid use disorder. 200 participants in Baltimore were assigned to either the peer-led support program or standard care. The goal was…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: University of Maryland, College Park • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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School program targets teen personalities to curb drug use
Prevention CompletedThis study tested a school-based program called Preventure in 3,900 Canadian teens. The program targets four personality traits linked to substance misuse, aiming to delay or prevent alcohol and drug use. Researchers also measured whether delaying substance use helps protect cogn…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: St. Justine's Hospital • Aim: Prevention
Last updated Jun 27, 2026 12:08 UTC
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Web program aims to keep teens from driving drunk or high
Prevention CompletedThis study tested a single online session called webCHAT to see if it could reduce impaired driving among teens. 198 adolescents aged 15.5 to 17 who were enrolled in driver education took part. The program aimed to help them make safer choices about alcohol, cannabis, and driving…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: Stanford University • Aim: Prevention
Last updated Jun 27, 2026 12:01 UTC
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New therapy shows promise for healing war wounds in rwanda
Symptom relief CompletedThis study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: Alexandros Lordos, PhD • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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Personalized craving scale shows promise for addiction treatment
Symptom relief CompletedThis study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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New workshop aims to ease Veterans' return to civilian life
Symptom relief CompletedThis study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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CBD shows promise in easing opioid cravings and anxiety
Symptom relief CompletedThis study looked at how cannabidiol (CBD) affects the brain in people with opioid use disorder who are also taking methadone. Researchers used brain scans to see if CBD could reduce cravings and anxiety. The study involved 66 adults and tested a single dose of CBD or a placebo, …
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: PHASE2 • Sponsor: Yasmin Hurd • Aim: Symptom relief
Last updated Jun 27, 2026 07:55 UTC
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New training aims to boost mental health crisis response in tribal nations
Knowledge-focused CompletedThis study tested a culturally tailored mental health training called First Face for Mental Health in seven Tribal nations. Over 550 participants completed surveys before and after training to see if it increased knowledge, confidence, and ability to help during a mental health c…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: Cambridge Health Alliance • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Brain scans reveal hidden effects of opioid use in pregnancy
Knowledge-focused CompletedThis study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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AI uncovers hidden addiction types in landmark study
Knowledge-focused CompletedThis study used artificial intelligence to analyze personality and behavior data from 155 adults in residential treatment for substance use disorder. The goal was to find hidden subtypes of addiction that could lead to more personalized treatment. No treatment was given; the stud…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Sponsor: Lauro Gutiérrez Castro • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Can a family training app help break the opioid crisis? new study says maybe.
Knowledge-focused CompletedThis study tested a digital version of a family training program called CRAFT. It was designed to help concerned family members (called CSOs) encourage a loved one with opioid use disorder to enter treatment. 45 adults who had a loved one struggling with opioid use participated. …
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: We The Village, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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New study checks if depression scale works for those with addiction
Knowledge-focused CompletedThis study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Sponsor: Lauro Gutiérrez Castro • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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AI could help hospitals identify hidden substance abuse
Knowledge-focused CompletedThis study developed a computer program that can scan hospital records to find patients who may be misusing drugs or alcohol. Researchers tested it on nearly 65,000 adults admitted to the hospital. The goal was to see if the tool could help doctors offer counseling and support to…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
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Study simulates ban on cigarette filter holes to see if smokers switch
Knowledge-focused CompletedThis study looked at what might happen if cigarette filter ventilation holes were banned. Researchers created a virtual store where 142 smokers could buy different tobacco products at various prices. The goal was to see how smokers would react if only low-ventilated or non-ventil…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: Virginia Polytechnic Institute and State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Fitbit for recovery: study tests activity trackers in alcohol treatment
Knowledge-focused CompletedThis study looked at whether using a Fitbit activity tracker can help people receiving inpatient treatment for alcohol use disorder increase their physical activity and improve their emotional state. Ninety adults in treatment wore the tracker and completed questionnaires about t…
Matched conditions: SUBSTANCE-RELATED DISORDERS
Phase: NA • Sponsor: University of Oviedo • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC