SEVERE ASTHMA

This phase 3 trial is testing whether people with severe asthma who take the drug Tezepelumab can safely cut back on their other daily asthma medications without losing control of their symptoms. About 400 participants aged 12 to 80 will be enrolled. The goal is to see if they ca…

This Phase 3 trial tests an injectable drug called TQC2731 in 660 adults with severe asthma that is not well controlled by high-dose inhalers. Participants will receive either the drug or a placebo every 4 weeks for a year. The goal is to see if the drug reduces asthma attacks an…

This trial tests whether a 6-month personalized exercise program improves exercise capacity and asthma control in adults with severe asthma who are starting biologic therapy. Participants are randomly assigned to either the exercise program or standard advice to increase physical…

This phase 3 trial tests whether GB-0895, given every 6 months, can reduce asthma attacks in adults and teens (ages 12–80) with severe asthma that isn't controlled by standard inhalers. About 786 participants will receive either GB-0895 or a placebo, and researchers will track ho…

This study tests a new medicine called GB-0895 for people aged 12 to 80 with severe asthma that is not controlled by standard inhalers. Participants receive either GB-0895 or a placebo as a shot every 6 months for a year. The goal is to see if GB-0895 can reduce the number of ser…

This study tests a drug called benralizumab (Fasenra) in 20 adults with severe asthma and a fungal allergy called ABPA. The goal is to see if it can reduce asthma flare-ups that need steroids and improve quality of life. Participants receive the drug as a shot under the skin, and…

This study is observing 225 adults with severe allergic asthma or chronic hives who are already doing well on the original omalizumab drug. Their doctors have decided to switch them to a biosimilar version called Omlyclo. The main goal is to see if they stay well-controlled for 1…

This study tests a procedure called bronchial thermoplasty (BT) for adults with severe asthma that remains uncontrolled even with biologic drugs. BT uses a thin tube to deliver heat to the airway walls, aiming to reduce muscle overreactivity. Researchers will compare asthma attac…

This study tests a new medicine called FB704A in adults with severe asthma. The goal is to see if it is safe and can help control asthma symptoms. About 20 people will receive either the drug or a placebo over 8 weeks, with follow-up for 12 more weeks.

This study looks at how mucus plugs in the lungs affect breathing in people with severe asthma. Researchers will use special MRI scans to see air flow in blocked areas. Only 5 adults with severe asthma will take part, and the goal is to better understand lung function, not to tes…

This study is observing 5,000 adults in Russia with severe, uncontrolled asthma who are not taking biologic medications. Researchers will collect information on their current treatments, health history, and lifestyle factors. The goal is to better understand how these patients ar…

This study tracks over 16,000 teens and adults with severe asthma to see if the drug tezepelumab raises the risk of serious heart problems like heart attack, stroke, or heart-related death. Researchers will compare those taking tezepelumab to those on standard asthma treatments. …

This study looks at how asthma-related inflammation in the lungs might affect the brain and contribute to depression and anxiety. Researchers will compare brain scans, blood tests, and breathing tests between 100 adults with asthma and healthy volunteers. The goal is to understan…

This observational study will follow 500 adults in Taiwan who are receiving biologic treatments (such as omalizumab, mepolizumab, or dupilumab) for severe asthma. Researchers aim to see how well these drugs work in everyday practice, what factors predict better control, and how o…

This study is building a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, severe asthma, and psoriasis. Researchers will collect blood samples and track disease activity over time using standard medical scores. The goa…

This study is a registry that collects health information from 714 Canadian adults with severe asthma over five years. Researchers will track symptoms, medication use, and lung function to better understand the disease and how patients respond to current treatments. No new drugs …

This study is a registry that will collect information from 5,000 people with severe asthma over time. The goal is to better understand the disease, how well patients follow their treatment plans, and how different biologic medications work in everyday life. Participants must be …

This study aims to find out how many adults with severe asthma in Thailand achieve remission and what factors might help. Researchers will ask participants about their asthma symptoms, do breathing tests, and take a blood sample once. The study does not provide any treatment—it o…

This study is a global registry that collects health information from 500 adults with severe asthma. The goal is to track how patients respond to treatments and understand the disease better. The data will help researchers develop improved care and therapies for severe asthma.

This study looks back at how biologic drugs are being used to treat severe asthma in Hong Kong. Researchers will review the medical records of 360 adults to see which biologics are prescribed, how well they control asthma, and any side effects. The goal is to understand current p…

This study looks at how mucus plugs block airways in people with severe asthma. Using special xenon MRI scans, researchers will measure how these plugs affect breathing and gas exchange. Five adults with severe asthma will be scanned before and after starting biologic therapy to …