SARCOIDOSIS

This study compares a low-dose combination of prednisone and methotrexate to the standard higher-dose prednisone for people with active cardiac sarcoidosis—a condition where inflammation damages the heart. About 194 participants will be randomly assigned to one of the two treatme…

This study looks at how vitamin D levels relate to sarcoidosis severity and whether vitamin D supplements can improve lung function and quality of life. About 90 adults with sarcoidosis and low vitamin D will receive either standard vitamin D or a placebo. The goal is to see if c…

This study explores a new blood test that may detect active heart inflammation in people with sarcoidosis, a disease that can cause serious heart problems. Researchers will measure DNA fragments released from damaged heart cells in 120 participants, including healthy volunteers a…

This study tests if an 8-week virtual mindfulness program (MBSR) can reduce fatigue in people with sarcoidosis. 100 participants will either join the MBSR program or a monthly virtual support group. The goal is to see which approach better improves fatigue, anxiety, and depressio…

This study looks at the best way to reduce steroid medication in people with stable sarcoidosis, an inflammatory disease often affecting the lungs. About 100 adults on a low daily steroid dose will be randomly assigned to a standard or faster tapering schedule. The goal is to cut…

This study creates a long-term record of how sarcoidosis affects people's lives. Participants answer surveys about symptoms, diagnosis, treatments, and daily challenges, and can share their electronic health records. The goal is to learn more about the disease and support future …

This study is building a large database and sample bank from 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will use this information to find links between patient outcomes and biological markers. The goal is to…

This study is creating a registry and biobank for people with interstitial lung disease (ILD), including sarcoidosis, pulmonary fibrosis, and hypersensitivity pneumonitis. Researchers will collect medical data and biological samples from up to 1,000 participants to better underst…

This study tests a new imaging method called full-field optical coherence tomography (FFOCT) to see if it can quickly analyze small lung biopsy samples as accurately as standard lab tests. About 20 adults having a bronchoscopy for diagnosis or staging will participate. The goal i…

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track participants' health, treatments, and outcomes over time to better understand these conditions. The goal is to imp…

This study is looking for 1,000 people with a genetic heart condition called arrhythmogenic cardiomyopathy (AVC) or their family members. The goal is to discover new genes and blood markers that can predict who will get the disease, how it will progress, and who is at risk for da…

This study looks at how certain immune cells (monocytes and macrophages) behave in people with sarcoidosis, a disease that causes inflammation and lumps called granulomas. Researchers will compare these cells in sarcoidosis patients to those with tuberculosis. The goal is to lear…

This study aims to understand why some people with sarcoidosis get better while others develop long-term problems. Researchers will study genes, immune cells, and gut bacteria from 5000 participants, including healthy volunteers. The goal is to find ways to predict who will respo…

This study looks at how immune cells behave in lung cancer, sarcoidosis, and COPD. Researchers want to understand why some people don't respond to immunotherapy. They will study samples from 425 people, including patients and healthy volunteers. The goal is to find better, more p…