New combo therapy aims to tame heart sarcoidosis with fewer side effects

NCT ID NCT03593759

Recruiting now Disease control Sponsor: Ottawa Heart Institute Research Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This Phase 3 trial compares a low-dose combination of prednisone and methotrexate to standard high-dose prednisone for people with active cardiac sarcoidosis. Researchers hope the combo works just as well but causes fewer side effects and improves quality of life. The study plans to enroll 194 participants across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: prednisone or prednisolone combined with methotrexate
What this could lead to: If successful, this could offer a safer, equally effective treatment option for cardiac sarcoidosis, reducing side effects from high-dose steroids.
What could go wrong: This is a Phase 3 trial, but it's still relatively small (194 participants). The combination therapy may not be as effective as standard treatment, and both drugs have known risks like infection and liver toxicity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiac sarcoidosis sarcoidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC SARCOIDOSIS SARCOIDOSIS

Contacts and locations

Locations

Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Auckland City Hospital
RECRUITING

Auckland, Grafton, 1023, New Zealand
CIUSSS de l'Estrie - CHUS - Hôpital Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
CIUSSS-Hopital du Sacre-Coeur de Montreal
RECRUITING

Montreal, Quebec, H4J 1C5, Canada
Chiba University
RECRUITING

Chiba, Japan
Eastern Health Health Sciences Centre
RECRUITING

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Hokkaido University
RECRUITING

Sapporo, Kita 8, Nishi 5, Kita-Ku, 060-0808, Japan
Imperial College Healthcare Trust-NHS-Hammersmith Hospital
NOT_YET_RECRUITING

London, W12 0HS, United Kingdom
Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval
RECRUITING

Québec, Quebec, G1V 4G5, Canada
King's College Hospital NHS Foundation Trust
NOT_YET_RECRUITING

London, SE5 9RS, United Kingdom
Libin Cardiovascular Institute of Alberta
RECRUITING

Calgary, Alberta, T2N 2T9, Canada
London Health Sciences Centre
RECRUITING

London, Ontario, N6A 4A5, Canada
Montefiore Medical Center
RECRUITING

New York, New York, 10467, United States
Montreal Heart Institute
RECRUITING

Montreal, Quebec, H1T 1C8, Canada
Nagoya City University
RECRUITING

Nagoya, Japan
National Cerebral and Cardiovascular Center (NCVC)
RECRUITING

Osaka, Japan
Nippon Medical School
RECRUITING

Tokyo, Japan
QE II Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, B3H 3A7, Canada
Sapporo Medical University
RECRUITING

Sapporo, Japan
St. Joseph's Healthcare Centre
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada
St. Marrianna University
NOT_YET_RECRUITING

Kawasaki, Japan
St. Paul's Hospital
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
The Ohio State University Wexner Medical Center
RECRUITING

Columbus, Ohio, 43210, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
University of Fukui
NOT_YET_RECRUITING

Fukui, Japan
University of Michigan-Michigan Medicine Cardiovascular Center
RECRUITING

Ann Arbor, Michigan, 48109-5853, United States
University of Minnesota
NOT_YET_RECRUITING

Minneota, Minnesota, 55455, United States
University of Ottawa Heart Institute
RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298-0053, United States
Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06520, United States

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