New combo therapy aims to tame heart sarcoidosis with fewer side effects
NCT ID NCT03593759
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial compares a low-dose combination of prednisone and methotrexate to standard high-dose prednisone for people with active cardiac sarcoidosis. Researchers hope the combo works just as well but causes fewer side effects and improves quality of life. The study plans to enroll 194 participants across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
prednisone or prednisolone combined with methotrexate
What this could lead to
If successful, this could offer a safer, equally effective treatment option for cardiac sarcoidosis, reducing side effects from high-dose steroids.
What could go wrong
This is a Phase 3 trial, but it's still relatively small (194 participants). The combination therapy may not be as effective as standard treatment, and both drugs have known risks like infection and liver toxicity.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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CIUSSS de l'Estrie - CHUS - Hôpital Fleurimont
RECRUITINGSherbrooke, Quebec, J1H 5N4, Canada
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CIUSSS-Hopital du Sacre-Coeur de Montreal
RECRUITINGMontreal, Quebec, H4J 1C5, Canada
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Chiba University
RECRUITINGChiba, Japan
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Eastern Health Health Sciences Centre
RECRUITINGSt. John's, Newfoundland and Labrador, A1B 3V6, Canada
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Hokkaido University
RECRUITINGSapporo, Kita 8, Nishi 5, Kita-Ku, 060-0808, Japan
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Imperial College Healthcare Trust-NHS-Hammersmith Hospital
NOT_YET_RECRUITINGLondon, W12 0HS, United Kingdom
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Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval
RECRUITINGQuébec, Quebec, G1V 4G5, Canada
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King's College Hospital NHS Foundation Trust
NOT_YET_RECRUITINGLondon, SE5 9RS, United Kingdom
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Libin Cardiovascular Institute of Alberta
RECRUITINGCalgary, Alberta, T2N 2T9, Canada
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London Health Sciences Centre
RECRUITINGLondon, Ontario, N6A 4A5, Canada
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Montefiore Medical Center
RECRUITINGNew York, New York, 10467, United States
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Montreal Heart Institute
RECRUITINGMontreal, Quebec, H1T 1C8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nagoya City University
RECRUITINGNagoya, Japan
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National Cerebral and Cardiovascular Center (NCVC)
RECRUITINGOsaka, Japan
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Nippon Medical School
RECRUITINGTokyo, Japan
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QE II Health Sciences Centre
RECRUITINGHalifax, Nova Scotia, B3H 3A7, Canada
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Sapporo Medical University
RECRUITINGSapporo, Japan
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St. Joseph's Healthcare Centre
RECRUITINGHamilton, Ontario, L8N 4A6, Canada
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St. Marrianna University
NOT_YET_RECRUITINGKawasaki, Japan
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St. Paul's Hospital
RECRUITINGVancouver, British Columbia, V5Z 1M9, Canada
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The Ohio State University Wexner Medical Center
RECRUITINGColumbus, Ohio, 43210, United States
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Tufts Medical Center
RECRUITINGBoston, Massachusetts, 02111, United States
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University of Fukui
NOT_YET_RECRUITINGFukui, Japan
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University of Michigan-Michigan Medicine Cardiovascular Center
RECRUITINGAnn Arbor, Michigan, 48109-5853, United States
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University of Minnesota
NOT_YET_RECRUITINGMinneota, Minnesota, 55455, United States
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University of Ottawa Heart Institute
RECRUITINGOttawa, Ontario, K1Y 4W7, Canada
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University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23298-0053, United States
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Yale-New Haven Hospital
RECRUITINGNew Haven, Connecticut, 06520, United States
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