PULMONARY DISEASE, CHRONIC OBSTRUCTIVE

This phase 2 trial tested an experimental inhaled powder called TQC3721 in 195 people with moderate to severe COPD. The goal was to see if it improves lung function and is safe compared to a placebo. Researchers measured changes in breathing capacity over four weeks.

This study tested a 12-week internet-based aftercare program for people with COPD, starting right after they finished inpatient pulmonary rehabilitation. The program included activity tracking, online exercise training, educational modules, and therapist support via phone. Resear…

This phase 2 trial tested whether infusions of PROCHYMAL, a stem cell product, are safe and can help people with moderate to severe COPD. 62 participants received either stem cells or a placebo. The main goal was to check for side effects, and researchers also looked at changes i…

This study tested whether high-flow nasal oxygen therapy works as well as standard noninvasive ventilation for people with a moderate COPD flare-up. Fifty-one patients were randomly assigned to one of the two treatments for the first 24 hours. The main goal was to see how each me…

This study looked at how well a single inhaler containing three medicines (Trelegy Ellipta) works for people with chronic obstructive pulmonary disease (COPD) in real-world settings. Over 12 weeks, 463 adults aged 40 and older with ongoing COPD symptoms used the inhaler. Research…

This Phase 2 trial tested an experimental drug called 611 in 142 Chinese adults with moderate-to-severe COPD. Participants received either 611 or a placebo as a shot under the skin every two weeks. The study measured changes in lung function and symptom scores over 16 weeks to se…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This study tested a new scoring tool (GLORI-COPD) to see how well it can identify COPD patients at risk of serious complications, like lung infections. Researchers studied 462 smokers or former smokers aged 35 and older who had not been previously diagnosed with COPD. The goal is…

This study looked at whether a blood test for circulating tumor cells (CTCs) can help detect lung cancer earlier in people at very high risk: smokers and ex-smokers with COPD. Researchers combined this blood test with low-dose CT scans over three yearly screenings in 683 particip…

This study tested whether teaching COPD patients breathing exercises through short videos could reduce shortness of breath, increase activity, and improve sleep. Sixty adults with COPD followed a 30-day program of pursed-lip and diaphragmatic breathing, guided by a 5-7 minute vid…

This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks a…

This study tested whether a combination inhaler (Glycopyrrolate/Formoterol) helps people with COPD exercise longer compared to a placebo. 52 participants with stable COPD completed the trial. The main goal was to measure any increase in exercise time on a stationary bike.

This study tested whether a home-based program combining physical and cognitive exercises is feasible for people with COPD. Twenty-four adults aged 50 and older with moderate COPD participated in an 8-week program. The goal was to see if patients could stick with the training and…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested a new sensor placed inside the nose to measure carbon dioxide levels in 21 people with breathing conditions like COPD or obesity-related breathing problems. The goal was to see if the sensor is safe, easy to use, and gives accurate readings compared to standard …

This early study tested a single dose of the experimental drug GSK3862995B in 30 healthy adults of Chinese, Japanese, and European ancestry. The goal was to see if the drug is processed similarly across these groups, so that future global COPD studies can include diverse particip…

This study looked at whether specific cells from the blood, called fibrocytes, are involved in muscle wasting (sarcopenia) in people with COPD. Researchers compared thigh muscle samples from 22 COPD patients with and without muscle loss. The goal was to understand why muscle loss…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested a wearable smart textile sensor system called SimpleSense in 334 people. The device uses special sensors in a harness to record heart signals, breathing, and body movement. Researchers compared its readings to standard hospital monitors to see if it works just a…

This study tested whether CT scans can better measure bone health and predict fracture risk in 560 smokers with and without COPD. Researchers used CT images of the spine and ankle to assess bone structure, alongside standard bone density tests. The goal is to create a more accura…

This study tested whether a wearable device (Vivalink) could track health signs like heart rate, breathing, and activity in people with COPD. 77 participants wore the device for 3 months to see if the data could predict when symptoms would get worse. The goal was to find a way to…

This study looked at how the heart and lungs of 10 people with moderate COPD respond to a 30-minute exercise test with short, intense work periods. Researchers measured blood pressure in the lungs and overall heart function. They found that lung blood pressure did not spike dange…

This study followed 216 people with COPD and other health conditions for up to 38 months. Participants used a mobile app to log daily symptoms and other health data. The goal was to find patterns that could predict when a person might have a flare-up or get worse, so doctors can …

This study looked at how breathing through a facemask-like resistance affects exercise in people with chronic obstructive pulmonary disease (COPD). 52 volunteers walked on a treadmill with and without added resistance to measure shortness of breath and effort. The goal was to und…

This study followed 31 adults with COPD for 12 weeks to track how their inflammation levels, lung function, and symptoms change over time. Researchers measured daily lung function and symptoms, along with weekly or biweekly blood and sputum tests. The goal was to better understan…

This study looked at how people with chronic heart failure or COPD process protein from meals. Researchers measured muscle building, body composition, and gut function in 90 adults aged 45 and older. The goal was to understand why muscle loss happens and how to design better diet…