POST-TRAUMATIC STRESS DISORDER (PTSD)

This study compares two treatments for veterans with PTSD who are at high risk for suicide. One combines Dialectical Behavior Therapy (DBT) with a PTSD-focused exposure therapy; the other is the current standard VA care. Researchers want to see which better reduces suicidal behav…

This study tests a new stepped care program called PCT+2HOPE for women with opioid use disorder who have also experienced intimate partner violence and PTSD. The program adds counseling and support to standard medication treatment, with the goal of helping women stay in treatment…

This study tests whether adding oxytocin (a natural hormone) nasal spray to a brief couples therapy can improve PTSD symptoms and relationship satisfaction in veterans. About 240 veterans and their partners will take part. The therapy focuses on communication and trust, and the o…

This study tests whether a special computer-based brain training program can help adults with PTSD improve memory, attention, and daily functioning. Participants will be randomly assigned to either the brain training program or regular computer games, both with group discussions,…

This study tests a new, faster version of transcranial magnetic stimulation (TMS) for PTSD. Instead of 6-7 weeks of daily sessions, participants receive 10 imaging-guided treatments per day for just 5 days. The goal is to see if this accelerated approach can quickly reduce PTSD s…

This study tests whether brief, educational videos sent by text message can help young people aged 15 to 25 manage symptoms of post-traumatic stress disorder (PTSD). About 98 participants across Canada will either receive the videos right away or wait several months. The goal is …

This study tests a software program designed to reduce symptoms of post-traumatic stress disorder (PTSD). About 52 adults with PTSD will use the software or a placebo version. Researchers will measure changes in PTSD severity using a standard scale over the study period.

This small early study tests whether a gentle brain stimulation technique called temporal interference (TI) can safely reduce PTSD symptoms in 5 adults. Participants will receive TI stimulation and have their brain activity measured with MRI, MEG, and EEG. The goal is to see if s…

This study tests whether giving ketamine during surgery can reduce pain, lower the need for opioids, and improve depression and PTSD symptoms in adults with serious orthopedic injuries. About 90 participants will be randomly assigned to receive either ketamine or standard anesthe…

This study is testing a type of talking therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. Researchers want to see if this approach is helpful and acceptable for 20 participants. The goal is to r…

This early-phase study tests whether a sublingual form of dexmedetomidine (BXCL501) is safe and shows promise for treating alcohol use disorder in people who also have PTSD. Ten heavy drinkers with PTSD will take the drug and be monitored for changes in blood pressure, anxiety, a…

This study tests if transcranial magnetic stimulation (TMS) is a safe and helpful treatment for teens aged 12-20 who still have PTSD symptoms after finishing talk therapy. About 20 participants will receive 10 TMS sessions over a month. The goal is to see if TMS reduces symptoms …

This study tests whether a type of therapy called EMDR can help reduce post-traumatic stress and emotional distress in people with advanced thyroid cancer. Researchers will combine group and individual EMDR sessions. The goal is to see if this approach is practical and helpful fo…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device is designed to improve sleep quality by interrupting nightmares. Researchers also want to see if better sleep leads to improved cardiovascular health. …

This study tests a specially adapted version of an adult PTSD treatment for children aged 6-14. The therapy uses games and child-friendly language to help kids safely replay and reduce fear from traumatic memories. Up to 40 children will attend six sessions with a trained special…

This study tests a program called NurseNET, where nurses are trained to provide a short-term PTSD therapy called Narrative Exposure Therapy. The goal is to make PTSD treatment more accessible for people who see their primary care doctor. Researchers will enroll 100 adults with PT…

This study tests whether a 2-week, fully remote program combining mild brain stimulation (tDCS) with prolonged exposure therapy can reduce chronic pain and PTSD symptoms. About 146 adults with both conditions will receive either real or sham stimulation alongside therapy, all fro…

This study tests whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants attend online group sessions and use a WeChat mini-program for daily exerci…

This study tests whether a small, handheld device that gently stimulates the vagus nerve (called gammaCore) can safely reduce PTSD symptoms. About 40 adults with PTSD will use the device at home daily for 12 weeks. Researchers will track symptom changes and any side effects to se…

This study tests whether group sessions teaching mind-body skills (like relaxation and meditation) can reduce PTSD and emotional problems in 120 adolescents aged 11-17 in Gaza who have experienced war trauma. Participants attend five group sessions and complete surveys before, af…

This study tests a new way to deliver trauma-focused therapy to teens aged 12-17 with PTSD. It combines a secure mobile app with video and in-person therapy sessions. The goal is to see if this blended approach is practical and helpful for teens, their families, and therapists in…

This study tests a new therapy called the Reconsolidation of Traumatic Memories (RTM) Protocol for people with PTSD in Ukraine. The goal is to reduce distressing symptoms like flashbacks and anxiety without requiring patients to relive their trauma in detail. The study will invol…

This study uses a special PET scan tracer to measure a brain protein called PDE4B in people with PTSD or alcohol use disorder. Researchers want to see if levels of this protein differ from healthy individuals. The study involves 160 adults aged 18 to 70 and does not offer treatme…