ORAL SQUAMOUS CELL CARCINOMA

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink tumors in people with advanced head and neck cancer that has returned or spread after initial treatment. About 40 adults whose cancer worsened after first-line therapy will receive the c…

This study tests three new treatments that deliver cancer-fighting drugs directly to tumors in the mouth or lungs. The goal is to shrink or eliminate cancer with fewer side effects than standard treatments. About 40 adults with early-stage oral or lung cancer will receive a topic…

This study tests whether giving antibiotics before surgery can lower the amount of bacteria found inside oral cancer tumors. About 30 adults with oral cancer will receive metronidazole and a special mouthwash before their planned surgery. Researchers will compare bacteria levels …

This study tests whether a special CT scan (dual-energy CT) works as well as MRI for staging mouth and throat cancers. If it does, patients may need one less scan, speeding up treatment and freeing up MRI machines. The study will enroll 30 adults with these cancers and compare th…

This study looks at whether certain DNA changes in saliva can help diagnose oral cancer (squamous cell carcinoma) more accurately. Researchers will collect saliva from 30 patients with oral cancer and compare it to healthy controls, both before and after tumor removal surgery. Th…

This study is testing a new, high-frequency ultrasound that goes inside the mouth to look at oral cancer. The goal is to see how deep the cancer goes without needing a surgical biopsy. About 400 people with oral squamous cell carcinoma will get this painless scan before their pla…