METASTATIC PROSTATE CARCINOMA

This early-stage trial tests a new treatment for men with a type of advanced prostate cancer that no longer responds to hormone therapy. The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. Some participants w…

This study tests whether adding PET-guided radiation to standard hormone therapy can better control metastatic prostate cancer that still responds to hormones. About 125 men with stage IVB prostate cancer will either receive standard treatment alone or standard treatment plus rad…

This study tests the drug talazoparib in adults with advanced solid tumors (like breast, prostate, ovarian, pancreatic, or stomach cancer) that have certain gene changes affecting DNA repair. The drug blocks a protein called PARP, which cancer cells need to fix their DNA, potenti…

This study is for men whose prostate cancer has come back (shown by rising PSA levels) after their prostate was removed. It tests whether using PET scans to guide more personalized treatment—adding the drug apalutamide with or without targeted radiation—works better than standard…

This early-stage study tests a treatment called bipolar androgen therapy for men with advanced prostate cancer that no longer responds to standard hormone therapy and has spread. The approach rapidly switches testosterone levels from very low to very high to shock cancer cells an…

This study looks at whether giving cancer therapy at home is safer and more satisfying for Black men with advanced prostate cancer compared to receiving it in a clinic. About 38 participants will try both settings and rate their experience. The goal is to reduce stress and improv…

This study tests whether using bright white light therapy glasses can reduce fatigue and improve mood in men with advanced prostate cancer who are receiving hormone therapy (ADT) combined with other treatments. About 210 men will either start light therapy right away or wait a fe…

This study tests whether a 16-week supervised exercise program (circuit training with resistance, functional, and aerobic exercises) can improve frailty, muscle loss, and inflammation in men with metastatic prostate cancer who are on hormone therapy. The study will include 80 men…

This study tests whether freezing bone tumors (cryoablation) before giving radiation therapy works better than radiation alone for reducing pain. About 40 adults with cancer that has spread to the bones will be enrolled. The goal is to see if the combination provides more complet…

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems in the cancer affect how well the drug radium-223 works. The goal is to help doctors choose better treatments in the future. About 48 men wil…

This study looks at how common low vitamin D levels are in African American men with prostate cancer, and whether correcting those levels can improve immune function. Researchers will measure vitamin D and immune cells in blood samples before and after supplementation. The goal i…

This study tests whether a computer-generated character (called PERLA) can help cancer patients learn about genetic testing as well as a human counselor does. The goal is to make genetic testing easier to access for people who often miss out, like those in rural areas or who spea…

This study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with prostate cancer that has spread understand and complete genetic testing. Genetic testing is important for treatment decisions, but many Afri…

This study looks at why some advanced prostate cancers become resistant to a treatment called 177Lu-PSMA. Researchers will take small tissue samples (biopsies) from tumors during treatment to find genetic changes that cause resistance. The goal is to learn how to make treatments …