LUNG DISEASES

This study is testing the safety of a new inhaled drug, mosliciguat, when added to an existing inhaled medication (treprostinil) for people with pulmonary hypertension caused by scarred lungs (interstitial lung disease). It will enroll about 20 participants who are already using …

This study is testing whether adding an inhaled antibiotic called ARIKAYCE® to standard oral drugs can better treat Mycobacterium xenopi lung infections. It will enroll 190 adults with this specific infection to see if the inhaled medicine helps patients clear the bacteria from t…

This study is testing whether the drug teniposide can help control advanced small cell lung cancer that has worsened despite standard chemotherapy. It is for patients whose cancer has a specific genetic feature called 'c-Myc-driven.' The main goal is to see if the drug shrinks tu…

This study is testing a drug called belumosudil in adults who have developed early or new lung scarring (Bronchiolitis Obliterans Syndrome) after a stem cell transplant. The goal is to see if the drug can improve lung function and stop the scarring from getting worse. About 45 pa…

This study is testing if using a blood test (ctDNA) to guide treatment decisions helps people with advanced lung cancer live longer. All 63 participants will first receive an immunotherapy drug (cemiplimab). After two cycles, doctors will check the blood test results and the pati…

This study is testing a new, non-invasive imaging technology called Electrical Impedance Tomography (EIT) to see if it can effectively monitor lung function. It aims to create a real-time 'map' of breathing in patients with lung diseases like COPD, asthma, and pulmonary fibrosis.…

This study is testing whether molecules collected from a person's cough can act as a 'liquid biopsy' to detect early signs of lung cancer and other lung diseases. Researchers will compare cough samples to samples taken during invasive bronchoscopy procedures to see if they provid…

This study is observing how well a robotic system works in real hospitals to help doctors locate and take samples from suspicious spots in the lungs. It will follow 3,000 patients who are already scheduled to have this robotic-assisted biopsy procedure. The main goal is to see ho…

This study aims to understand how bedside lung ultrasound can help monitor critically ill pregnant women and gynecological patients in intensive care. Researchers will observe 64 patients to see what lung problems ultrasound can detect and whether these findings relate to patient…

This study aims to learn what healthy lungs look like in young adults aged 25-35. Researchers will observe 1000 participants, taking detailed measurements of their lung structure and function. The goal is to identify early signs of future lung problems and understand how lifestyl…

This study aims to understand what 'healthy lungs' look like in young adults and identify early warning signs for future lung disease. It will follow 4,000 healthy people aged 25-35 for several years, tracking their lifestyle, environment, and lung function. The goal is to learn …

This study aims to develop better tests to predict when a transplanted lung might start failing. Researchers will follow 244 lung transplant patients over time, collecting blood samples to analyze DNA fragments and immune cells. The goal is to create a model that can spot early w…

This study aims to measure how much effort it takes for children with muscle or lung diseases to breathe. Researchers will use a small tube to measure pressures in the chest and stomach of up to 550 children. The goal is to better understand their breathing difficulties to help g…

This study aims to collect lung sounds from patients to train a computer program (AI) to recognize abnormal sounds like wheezes and crackles. Doctors will use special digital stethoscopes during regular check-ups to record sounds from up to 250 people, including those with and wi…

This study aims to develop a better, standardized technique for using freezing catheters to take lung tissue samples and treat lung lesions. Researchers will test the procedure on donated human lungs to see if it can be a safer, less invasive alternative to current surgical metho…

This study collects blood and tissue samples from people with advanced lung diseases or who have had lung transplants. Researchers will store these samples in a biobank to study them later, looking for biological markers that could help diagnose conditions earlier or predict how …

This study aims to collect recordings of normal and abnormal lung sounds from up to 200 adult patients. Doctors will use a digital stethoscope during regular check-ups to record sounds like wheezes and crackles. The recordings will be used to train a computer program to automatic…