LUNG DISEASES

This study tests whether a combination of two drugs (sacituzumab and zimberelimab) can prevent lung cancer from coming back after surgery. It is for people with stage IB to IIIB non-small cell lung cancer whose tumor did not fully disappear after pre-surgery treatment. About 129 …

This study is for people with advanced non-small cell lung cancer whose tumors have high PD-L1 levels. Researchers want to see if a blood test that measures tumor DNA (ctDNA) can help decide whether to add chemotherapy to the immunotherapy drug cemiplimab. About 63 participants w…

This study tests whether adding a new inhaled drug, mosliciguat, to an existing treatment (treprostinil) is safe for people with high blood pressure in the lungs caused by lung scarring. About 20 adults with this condition will receive the combination and be monitored for side ef…

This study tests whether adding an inhaled antibiotic (amikacin liposome suspension) to standard treatment helps clear a rare lung infection caused by Mycobacterium xenopi. About 190 adults with this infection will receive either standard care alone or standard care plus the inha…

This study tests a drug called teniposide in 15 people with advanced small cell lung cancer that has a specific gene change (c-Myc) and has stopped responding to standard treatments. The goal is to see if the drug can shrink tumors and control the disease. Participants must be in…

This study looks at whether monitoring the immune response to cytomegalovirus (CMV) can help prevent CMV disease in lung transplant recipients. About 100 adults who are CMV-positive and awaiting a lung transplant will have their CMV immunity tracked after surgery. The goal is to …

This study tests a new drug called belumosudil for people who develop a serious lung condition (bronchiolitis obliterans syndrome) after a stem cell transplant. The goal is to see if the drug can improve lung function or slow the disease. About 45 adults with new or early-stage l…

This study explores whether electrical impedance tomography (EIT), a non-invasive imaging method, can effectively monitor lung function and diagnose lung diseases like COPD, asthma, and pneumonia. Researchers will compare EIT results with standard spirometry in 400 adults, includ…

This study aims to see how well a robotic system works for finding and taking samples from suspicious spots in the lungs. It will observe 3,000 adults who are already scheduled to have this procedure as part of their regular care. The main goal is to measure how often the biopsy …

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples and destroy lung lesions. Researchers will measure ice ball temperatures, freezing times, and tissue sample sizes to find the safest and most effective techni…

This study gathers lung sound recordings from 200 adults (with and without breathing issues) using a digital stethoscope. The goal is to train a computer algorithm to automatically identify wheezes, crackles, and other abnormal sounds. No treatment is given; the study only collec…

This study is looking for better ways to predict if a lung transplant will start to fail. Researchers will use advanced blood tests to find early warning signs of rejection in 244 lung transplant recipients. The goal is to create a tool that helps doctors catch problems sooner an…

This study looks at whether a simple bedside lung ultrasound can help identify serious lung problems early in women admitted to the intensive care unit for pregnancy complications or gynecologic cancer. Researchers will track different ultrasound patterns and see if they are link…

This study collects blood and tissue samples from 100 adults who have had a lung transplant in the last 10 years. Researchers will use these samples to study biomarkers and how infections affect outcomes. The goal is to improve care for people with advanced lung disease, not to t…

This study looks at 1000 healthy people aged 25 to 35 to understand how their lungs and heart blood vessels are built and how well their lungs exchange gases. Researchers want to see if things like environment and general health are linked to lung structure and function. Particip…

This study tests a new way to manage breathing during lung cancer surgery. Normally, one lung is deflated during surgery, which can cause low oxygen levels and lung damage. The new method uses a tube to measure lung pressure and sets the ventilator to the best setting for each pa…

This study aims to develop a simple, non-invasive test for lung diseases like cancer by analyzing cough samples. Researchers will collect coughs, mouthwash, and lung fluid from 2,000 adults to see if genetic material from the lungs can be detected in breath. The goal is to create…

This study will collect lung sounds from 250 adults (including some children) using a special stethoscope-like device in real clinics. The goal is to train an artificial intelligence program to automatically recognize abnormal breathing sounds like wheezes and crackles. Participa…

This early-stage study tests a new tablet form of the experimental COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood with the new tablet compared to the original, and whether taking it with food or as a drink changes…

This study aims to better understand how hard it is for children with certain muscle, lung, or heart conditions to breathe. Researchers will use a thin tube to measure pressure in the chest and stomach in 550 children under 18. The goal is to learn more about breathing problems s…

This study follows 4,000 adults aged 25-35 without severe lung disease over many years. The goal is to learn what healthy lungs look like and find early warning signs of chronic lung disease. Participants will have breathing tests and other check-ups to track lung function over t…