LUNG DISEASES

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutant non-small cell lung cancer. It involves 532 adults with stage IIIB, IIIC, or IV disease who cannot have surgery or radiation. Researchers…

This study was designed to test a special catheter that delivers clot-dissolving medicine directly into the lungs of people with blood clots. The trial was withdrawn before enrolling any participants, so no results are available. It would have included adults aged 18 to 80 with s…

This phase 2 trial tests whether a combination of curcumin (from turmeric) and fish oil can reduce the size of lung nodules in former and current smokers aged 55 and older. Nineteen participants took the supplements or a placebo for 6 months. The study aims to see if the nodules …

This Phase 2 trial tests an inhaled medication called mosliciguat in 135 people who have both lung scarring (interstitial lung disease) and high blood pressure in the lungs. Participants are randomly assigned to receive either the drug or a placebo for 16 weeks. The study measure…

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug remains s…

This trial is testing a device called the Aventus Thrombectomy System, which suctions out blood clots from the lungs in people with acute pulmonary embolism. The study involves 130 participants aged 18 to 80. The goal is to see if the device is safe and effective at improving blo…

This program provides taletrectinib, a targeted cancer pill, to adults with advanced or metastatic ROS1-positive non-small cell lung cancer who cannot join a clinical trial or use approved treatments. Patients must have a ROS1 gene fusion and adequate organ function. The goal is …

This study looks at whether a bronchodilator (a drug that opens airways) can reduce shortness of breath and improve exercise ability in adults with cystic fibrosis. Twenty participants will receive either the drug or a placebo and then do exercise tests to compare their breathing…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study looks at whether educating doctors in small and mid-sized city hospitals can improve how they test and treat patients with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more patients get the right molecular tests and targeted treat…

This study is gathering lung sounds from 750 adults—both healthy volunteers and those with breathing issues—using special digital stethoscopes. The goal is to build an artificial intelligence algorithm that can automatically detect abnormal sounds like wheezes or crackles. If it …

This study is tracking over 1,300 people who are having a lung biopsy or lesion localization with the Ion Endoluminal System, a robotic device. The goal is to see how often the device successfully gets a diagnosis and how often complications like a collapsed lung or bleeding occu…

This study planned to give low-dose chest CT scans to firefighters aged 35 and older to see how many had lung cancer, other cancers, or lung diseases from job-related smoke and chemical exposure. It was withdrawn before any firefighters were enrolled, so no results are available.…

This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…

This study examines how different genes influence the severity of lung disease in people with cystic fibrosis. Researchers will analyze genetic data from 600 participants to identify gene variants linked to milder or more severe lung problems. The goal is to better understand the…