LUNG DISEASES

This study planned to test a special tube called the Versus Catheter for dissolving blood clots in the lungs. It aimed to see how well the catheter worked and how doctors liked using it. However, the study was withdrawn before any patients were enrolled, so no results are availab…

This program offers taletrectinib to adults with advanced or spreading ROS1-positive non-small cell lung cancer who cannot use approved treatments or join ongoing studies. Participants must have a ROS1 gene fusion and adequate organ function. The goal is to provide potential bene…

This study looks at how well the drug osimertinib combined with chemotherapy works as the first treatment for people with advanced EGFR-mutated non-small cell lung cancer. About 532 adults with stage IIIB, IIIC, or IV lung cancer that cannot be surgically removed are being observ…

This study tests a new device called the Aventus Thrombectomy System to safely remove blood clots from the lungs in people with a sudden, severe pulmonary embolism. About 130 adults aged 18 to 80 with symptoms lasting less than two weeks will be enrolled. The goal is to see if th…

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who have already been in earlier ralinepag studies will take the drug and be monitored f…

This study tests an inhaled medicine called mosliciguat in 135 people who have high blood pressure in their lungs due to scarring lung disease. The goal is to see if it improves blood flow and walking ability over 16 weeks. Participants are randomly assigned to receive the drug o…

This study tests whether a combination of fish oil (Lovaza) and curcumin (from turmeric root) can reduce the size of lung nodules in current and former smokers aged 55 and older. Nineteen participants took the supplements for 6 months to see if nodules shrank and if the treatment…

This study looks at whether educating doctors in smaller city and county hospitals can improve how they test and treat patients with advanced non-small cell lung cancer. About 1000 patients will be observed to see if more patients get the right molecular tests and targeted therap…

This study watches how diseases of the lungs, stomach, and hormones change brain metabolism using special PET scans. Researchers follow 200 adults over time to see if these brain changes can predict tumor return, spread, or survival. No treatment is given — the goal is to learn a…

This study aimed to give firefighters low-dose chest CT scans to check for lung cancer and other lung diseases caused by smoke and chemical exposure. It focused on firefighters aged 35 and older who never smoked or quit long ago. The study was withdrawn before enrolling anyone, s…

This study gathers lung sounds from 750 adults—both healthy and those with breathing problems—using a digital stethoscope. The goal is to build an artificial intelligence program that can automatically detect wheezes, crackles, and other abnormal sounds. No treatment is given; th…

This study looks at how different genes can make cystic fibrosis lung disease better or worse in different people. Researchers are studying 600 people with CF to find genetic clues that explain why some have milder lung problems. The goal is to learn more, not to test a new treat…