INTELLECTUAL DISABILITY

This study tested whether whole genome sequencing (WGS) can find more genetic causes of intellectual disability than current standard tests. Researchers compared WGS to usual methods in 3825 children and adults with unexplained intellectual disability. The goal was to see if WGS …

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study tested a training program called SAFE for people with intellectual or developmental disabilities who are working or looking for work. The program taught them about COVID-19, how to use protective gear, social distancing, and self-advocacy. 67 young adults took part, an…

This study tested a program where mothers and their children with intellectual disabilities (ages 6-12) did art activities together to improve their relationship and well-being. 157 mother-child pairs took part, with some receiving the art program and others continuing usual care…

This pilot study tested a 4-week laughter yoga program (8 sessions, 15 minutes each) in 45 adolescents with intellectual or physical disabilities at a special school in Hong Kong. Half did laughter yoga, half got routine care. The goal was to see if laughter yoga could improve mo…

This early-phase trial tested the safety of nabilone, a synthetic cannabinoid, in 20 adults with intellectual and developmental disabilities who have severe aggression. The goal was to see if the drug is well-tolerated and to gather initial data on whether it might reduce aggress…

This study tested whether metformin, a common diabetes medication, can help improve language, behavior, and weight problems in people with fragile X syndrome. 125 participants aged 6 to 35 took either metformin or a placebo for 4 months. Researchers measured changes in language s…

This study tested whether a structured program of therapeutic play activities could improve motor adaptive behavior in 20 Egyptian children aged 5-9 with mild intellectual disability. The children took part in 24 play sessions over 2 months, focusing on core strength, coordinatio…

This study tested whether cannabidiol (CBD) oil can reduce severe behavioral problems in children aged 6-18 with intellectual disability. 132 participants received either CBD or a placebo for 8 weeks. The main goal was to see if CBD improves irritability and other challenging beh…

This study looked at 8500 people with intellectual disability to find new genes that might cause it. Researchers used advanced DNA tools to compare patients and their healthy siblings. The goal was to identify unknown genetic causes and improve future diagnosis.

This study used eye-tracking to see how emotional expressions (low, medium, or high intensity) influence how children with autism understand intentions. Researchers watched where 80 children looked during a puzzle task. The goal was to learn more about attention patterns, not to …

This completed study used eye-tracking technology to understand how children with autism spectrum disorder (ASD), intellectual disability (ID), and typically developing children process visual cues. Researchers showed 80 children videos of a model choosing objects and recorded th…

This study looked at how 30 children aged 12-18 with mild intellectual disabilities learn tennis. One group used real-time pose recognition technology, while the other had standard instructor-led lessons. Over 14 weeks, researchers compared their learning experiences and motor sk…

This study tested a falls management tool adapted for adults with intellectual disabilities. 13 participants, including adults with intellectual disabilities, carers, and clinicians, tried the program and gave feedback on how easy it was to use. The goal was to see if the tool is…

This completed study looked at whether giving doctors access to genetic tests called FirstStepDx PLUS and NextStepDx PLUS helps them diagnose intellectual disability and developmental delay more accurately and cost-effectively. The study involved 217 pediatric neurologists, devel…

This study looked at the best ways to encourage COVID-19 testing for children with intellectual and developmental disabilities and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find what messages and strategies work best to k…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This study tested a reading program for 55 young adults with intellectual or developmental disabilities. Participants learned strategies to understand everyday texts like emails and messages during 45-minute sessions twice a week for three months. The goal was to see if the progr…

This study looked for brain markers of catatonia (a condition causing movement and behavior problems) in people with autism. Researchers used MRI scans to target a brain area with magnetic stimulation and measured brain activity and symptoms. The goal was to see if overactive bra…

This study followed 132 children and teens aged 7-18 with severe intellectual disabilities living in Chinese orphanages for three years. Researchers measured their physical fitness every three months using simple tests like throwing a beanbag, doing sit-ups, and standing on one l…