HYPOXEMIA

This study tests whether giving a 7-day course of corticosteroids (like prednisolone) to hospitalized adults with severe respiratory infections and low oxygen levels can reduce deaths and the need for breathing machines. About 3,000 participants will be randomly assigned to recei…

This study tests a new device that combines a mouthpiece, airway support, oxygen delivery, and breathing monitoring into one tool for sedated endoscopy. About 1,500 adults will be randomly assigned to receive either this device or standard care. The goal is to see if it reduces e…

This study compares two oxygen delivery devices—high-flow nasal cannula and Microstream Advance nasal cannula—during ERCP, a procedure done under deep sedation. The goal is to see which one better prevents oxygen desaturation. 74 adults scheduled for ERCP will be randomly assigne…

This study will test whether raising the head of the bed to 15 degrees reduces the chance of low oxygen levels during painless (sedated) gastroscopy and colonoscopy. About 400 adults will be randomly assigned to either a flat or slightly raised position. The goal is to see if thi…

This study looks at whether a special oxygen device (high-flow nasal cannula) can prevent dangerously low oxygen levels in children aged 1 to 6 years who are sedated for a lung exam called bronchoscopy. About 430 children will be randomly assigned to receive either the high-flow …

This study tests whether adding a real-time carbon dioxide monitor (capnography) to standard vital sign checks can catch breathing problems earlier during painless gastrointestinal endoscopy. Researchers will enroll 460 patients and track how often oxygen levels drop below 95%. I…

This study will test whether using higher or standard pressure on a ventilator during surgery helps patients breathe better after waking up. About 360 adults having planned non-chest, non-heart surgery will be randomly assigned to one of two pressure levels. The main goal is to s…

This study will follow 1,000 adults having a routine diagnostic endoscopy (camera test of the stomach or colon) with propofol sedation. Researchers want to find out which patients are more likely to have a dangerous drop in blood pressure or oxygen levels during the procedure. Th…

This study will observe 300 adults scheduled for a lung biopsy (EBUS-TBNA) to see if the size of their windpipe, measured by ultrasound before the procedure, can predict dangerous drops in oxygen levels. The procedure is done under sedation, and low oxygen is a known risk. The go…

This study looks at whether being frail increases the risk of dangerously low oxygen levels during a procedure called ERCP in people aged 65 and older. Researchers will assess frailty before the procedure and track oxygen levels during it. The goal is to create a simple tool that…

This study will check if a simple lung ultrasound done before, during, and after surgery can predict who will need extra oxygen or develop lung complications. Researchers will follow 97 adults having major non-chest surgery. The goal is to see if the ultrasound score is linked to…

This study watches 100 adults after a sedated upper GI endoscopy to see how often their oxygen levels drop below normal. Researchers will track these episodes and any breathing problems that follow, without changing standard care. The goal is to better understand and improve reco…

This study will check if a simple breathing measurement called the ROX index, taken before bariatric surgery, can predict which patients will have low oxygen levels in the first 12 hours after surgery. Researchers will measure the ROX index along with other risk scores in 80 adul…

This study compares giving 30% versus 100% oxygen to patients just before they wake up from abdominal surgery. The goal is to see if a lower oxygen level reduces the chance of low blood oxygen after the breathing tube is removed. About 590 adults will take part, and the results c…