GASTRIC CANCER (GC)

This early-phase study tests a personalized mRNA cancer vaccine (XH001) given alongside standard treatment after surgery for people with high-risk solid tumors (bile duct, gallbladder, pancreatic, liver, or stomach cancer). The main goals are to check safety and see if the vaccin…

This early-phase study tests an experimental drug called OKN4395, taken as a pill, alone or together with the immunotherapy pembrolizumab. The goal is to find a safe dose and see if the combination can shrink tumors in people with advanced solid cancers like lung, colorectal, sto…

This early-stage trial is testing a new drug called THE-0504 in 30 adults with advanced solid tumors, including lung, colon, stomach, breast, and pancreatic cancers. The main goal is to see if the drug is safe and to find the best dose. Researchers will also watch for any signs t…

This early-phase study tests a new drug called SH009 in people with advanced solid tumors (like liver, lung, breast, or stomach cancer) that have not responded to standard treatments. The main goals are to see if the drug shrinks tumors and to check its safety. About 150 adults w…

This phase 3 trial tests whether a chemotherapy combination of oxaliplatin plus S-1 works as well as or better than docetaxel plus S-1 for stage III gastric cancer patients who have had surgery. About 387 adults aged 18 to 80 will be randomly assigned to one of the two treatments…

This study looks at whether giving heated chemotherapy directly into the abdomen during surgery can help prevent stomach cancer from coming back. About 200 adults with advanced stomach cancer that has spread to the lining of the abdomen will receive the treatment. The goal is to …

This study tests a new combination of two experimental drugs (iparomlimab and tuvonralimab, together called QL1706) plus standard chemotherapy in people with advanced stomach or gastroesophageal junction cancer that hasn't been treated before. The goal is to see if this combo can…

This study tests a combination of three drugs (SHR-1701, rivoceranib, and possibly SHR-2554) in 40 adults with advanced stomach or gastroesophageal junction cancer that worsened after or could not tolerate first-line immunotherapy. The goal is to see if the new combo can shrink t…

This phase 2 trial tests whether adding radiotherapy and two immunotherapy drugs (iparomlimab and tuvonralimab) to standard chemotherapy can improve outcomes for people with resectable stomach or gastroesophageal junction cancer. About 40 participants will be randomly assigned to…

This study is testing a new type of PET/CT scan called [¹⁸F]FAPI-74 to see if it can better detect when stomach or esophageal cancer has spread to other parts of the body. About 200 adults with these cancers will receive one dose of the scan tracer and be followed for up to 3 mon…

This study is developing an artificial intelligence (AI) system to predict how well gastric cancer will respond to chemotherapy and immunotherapy given before surgery. Researchers will collect data from 2,000 patients with locally advanced gastric cancer. The AI will analyze stan…

This study is developing a blood test that looks for tiny genetic molecules called miRNAs, which can signal the presence of several gastrointestinal cancers like liver, pancreatic, and colorectal cancer. Researchers will analyze blood samples from 1,000 adults—half with cancer an…

This study tests a new imaging technique called iPPG, which uses light to measure blood flow, against the standard method using a green dye (ICG) during gastrointestinal surgery. The goal is to see if iPPG can predict and prevent anastomotic leaks—a serious complication where the…

This study looks at two different ways to reconnect the stomach after surgery for upper stomach cancer. The goal is to see which method causes less acid reflux and helps patients feel better and eat better. About 52 adults with early-stage stomach cancer will take part across six…

This study compares different ways to reconnect the digestive tract after removing the upper part of the stomach due to cancer. The goal is to find which method causes the fewest complications and gives patients the best quality of life. Researchers will follow 400 people in Russ…

This study aims to find the best range for removing No.4sb lymph nodes during surgery for advanced stomach cancer. Researchers will track 400 patients to see how often cancer spreads to different parts of these lymph nodes. The goal is to help surgeons remove only the necessary n…