GASTRIC CANCER (GC)

This early-stage trial is testing an experimental treatment called the IKS04 regimen in people with advanced cancers of the digestive system, including colorectal, stomach, pancreatic, and bile duct cancers. The regimen combines a targeted antibody-drug conjugate with an addition…

This study tests whether adding sodium propionate, a common food preservative, to standard immunotherapy and chemotherapy can improve tumor shrinkage in people with advanced stomach cancer. About 20 adults with inoperable gastric cancer will be randomly assigned to receive either…

This study tests a combination of three drugs (sintilimab, bevacizumab, and chemotherapy) in people with a rare and aggressive type of stomach cancer that produces a protein called AFP. The goal is to shrink the tumors enough so they can be surgically removed. About 46 adults wit…

This clinical trial is testing a new approach for people with advanced HER2-negative stomach or gastroesophageal junction cancer that cannot be removed by surgery. The treatment combines two immunotherapy drugs (iparomlimab and tuvonralimab) with standard chemotherapy (SOX) and a…

This study tests an experimental drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants w…

This study tests a new drug called JPI-547 combined with irinotecan for people with advanced stomach cancer that has come back or spread after at least two prior treatments. The goal is to see if the combination is safe and can shrink tumors. About 49 adults with good performance…

This study tests if robot-assisted surgery helps people with a certain type of stomach cancer live longer without the cancer coming back, compared to standard laparoscopy. About 335 adults aged 18-80 with stage cT4a stomach cancer will be randomly assigned to one of the two surgi…

This early-phase trial will test NK510, a cell therapy, in 15 people with advanced stomach or colorectal cancer that has come back or not responded to at least two prior treatments. NK510 is given through an IV or directly into the abdomen. The main goals are to check safety and …

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This study tests whether a special ultrasound technique, called contrast-enhanced subharmonic ultrasound, can predict if chemotherapy is working for stomach cancer that has spread to the liver. Currently, doctors wait about 2 months for CT or MRI scans to see tumor shrinkage. Thi…

This study explores a new way to diagnose gastric cancer by analyzing tiny particles called extracellular vesicles found in stomach fluid. Researchers will collect stomach fluid from 100 patients undergoing gastroscopy and use a special sensor to detect cancer-related changes. Th…

This study tests a new radioactive imaging agent called 68Ga-NOTA-GPA33 nanobody, which targets a protein (GPA33) found on some cancer cells. Researchers will use PET scans to see if this agent can better detect and stage colorectal, stomach, and pancreatic cancers in 56 patients…

This trial tests whether a nurse-led program combining an AI chatbot and home-based exercises can help advanced gastric cancer patients on immunotherapy feel less frail and have a better quality of life. Participants use the chatbot to report side effects and get personalized adv…

This study tests whether transcutaneous electrical acupoint stimulation (TEAS) — a needle-free treatment that sends mild electrical pulses through sticky pads on the skin — can help people recover faster after laparoscopic surgery for stomach cancer. Researchers are comparing thr…

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study looks at whether tumor DNA found in blood or peritoneal fluid can predict the spread of digestive cancers (stomach, colon, pancreas) to the lining of the abdomen. Researchers will follow 300 patients with early-stage tumors to see if those with positive DNA markers are…