FRONTOTEMPORAL DEMENTIA

This study tests a one-time gene therapy called PBFT02 for frontotemporal dementia (FTD) in adults who have a mutation in the GRN or C9ORF72 gene. The therapy aims to deliver a working copy of the GRN gene to the brain to help control the disease. About 30 participants will recei…

This study tests a new drug called DNL593 in healthy people and those with frontotemporal dementia (FTD), a brain disease that affects behavior and language. The goal is to check if the drug is safe and how the body processes it. About 85 participants will receive either DNL593 o…

This study tests a gene therapy called LY3884963 in 35 adults with frontotemporal dementia caused by a GRN gene mutation. The therapy is given as a single injection into the fluid around the brain to increase levels of a protective protein called progranulin. The goal is to see i…

This study tests whether metformin, a common diabetes drug, is safe and tolerable for people with a specific genetic form of ALS (C9orf72 ALS). About 41 participants will take metformin for 24 weeks. The goal is to see if it can reduce harmful proteins in the body that are linked…

This study explores whether making music together can improve social attention and emotional connection for people with frontotemporal dementia or Alzheimer's disease and their caregivers. About 80 pairs (patient and caregiver) will take part in rhythmic musical activities. The g…

This study tracks biological markers (biomarkers) in people with ALS and related disorders, as well as healthy volunteers, to better understand how these diseases progress. The goal is to help design better clinical trials for future treatments. No experimental treatments are giv…

This study follows 342 people from families with genetic mutations linked to frontotemporal dementia (FTD), along with a control group. Participants provide blood samples remotely every 3 months for 3 years to measure a protein called neurofilament light chain (NfL), which may si…

This study asks 1,000 people with neurological diseases like Alzheimer's or Parkinson's, and their caregivers, to share their experiences using a head device called MemorEM. The goal is to learn how to make the device better and easier to use in future studies. No treatment is gi…

This study aims to learn more about ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers will look at how a person's genetic makeup relates to their symptoms and will search for biological markers (biomarkers) in blood and spinal fl…

This study aims to see if a remote monitoring system using wearable sensors can effectively track movement symptoms in people with Progressive Supranuclear Palsy (PSP) and related disorders. About 60 participants will wear a pendant sensor for 12 months while researchers check th…