FRONTOTEMPORAL DEMENTIA
Clinical trials for FRONTOTEMPORAL DEMENTIA explained in plain language.
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New drug enters human testing for devastating brain disease
Disease control OngoingThis early-stage study is testing an investigational drug called DNL593 to see if it is safe and how it behaves in the body. It involves healthy volunteers and people diagnosed with frontotemporal dementia (FTD) who have a specific genetic mutation. The main goal is to check for …
Matched conditions: FRONTOTEMPORAL DEMENTIA
Phase: PHASE1, PHASE2 • Sponsor: Denali Therapeutics Inc. • Aim: Disease control
Last updated Apr 01, 2026 21:40 UTC
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Diabetes drug tested as potential new weapon against inherited ALS
Disease control OngoingThis study is testing whether metformin, a common diabetes medication, is safe and tolerable for people with a specific genetic form of ALS caused by a C9orf72 mutation. Researchers want to see if taking metformin for 24 weeks can reduce levels of harmful proteins in the brain an…
Matched conditions: FRONTOTEMPORAL DEMENTIA
Phase: PHASE2 • Sponsor: University of Florida • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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First human test of gene therapy for inherited dementia begins
Disease control OngoingThis is an early-stage study testing a new gene therapy called LY3884963 for people with a specific genetic form of frontotemporal dementia (FTD). The main goals are to check if the treatment is safe and to see if it can increase levels of a protective protein in the brain and sp…
Matched conditions: FRONTOTEMPORAL DEMENTIA
Phase: PHASE1, PHASE2 • Sponsor: Prevail Therapeutics • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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Can making music together help dementia patients connect?
Symptom relief OngoingThis study explores whether doing rhythmic music activities together can improve social attention and feelings of connection for people with mild to moderate frontotemporal dementia or Alzheimer's disease and their caregivers. Researchers will compare groups doing synchronized mu…
Matched conditions: FRONTOTEMPORAL DEMENTIA
Phase: NA • Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Mar 23, 2026 15:15 UTC
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Scientists hunt for clues in blood and spinal fluid to speed up ALS drug development
Knowledge-focused OngoingThis study aims to find and validate biological markers (biomarkers) in blood, urine, and spinal fluid from people with ALS and related disorders. The goal is to better understand the diseases and create tools to measure if future experimental treatments are working. It involves …
Matched conditions: FRONTOTEMPORAL DEMENTIA
Sponsor: University of Miami • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:43 UTC
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Wearable sensors track brain disease from home
Knowledge-focused OngoingThis study aims to develop and test a remote monitoring system for people with frontotemporal dementia and related disorders like Progressive Supranuclear Palsy (PSP). Researchers will enroll 60 participants with PSP and follow them for 12 months using wearable sensors and mobile…
Matched conditions: FRONTOTEMPORAL DEMENTIA
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Scientists track blood signal in families destined for dementia
Knowledge-focused OngoingThis study aims to track a specific protein in the blood (neurofilament light chain) over three years in people who carry a genetic risk for frontotemporal dementia (FTD). It involves 342 participants who will have blood drawn remotely four times a year. The goal is to see if thi…
Matched conditions: FRONTOTEMPORAL DEMENTIA
Sponsor: The Bluefield Project to Cure Frontotemporal Dementia • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:35 UTC
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Patients test brain device for Alzheimer's and Parkinson's feedback
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to gather feedback from patients with neurological diseases like Alzheimer's and Parkinson's about their experience using the MemorEM head device. About 1,000 patients and their caregivers will share their thoughts through monthly surveys to help improve the devic…
Matched conditions: FRONTOTEMPORAL DEMENTIA
Phase: NA • Sponsor: eQ8Health Corporation d/b/a CareONE Concierge • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:02 UTC