DEMENTIA WITH LEWY BODIES

This study tests whether ambroxol, a common cough medicine, can slow cognitive decline and improve symptoms in people with early Dementia with Lewy Bodies (DLB). Researchers will enroll 180 participants aged 50-85 with mild or early-stage DLB. The trial lasts 18 months and measur…

This pilot study tests whether a non-invasive brain stimulation technique called tDCS can reduce psychotic-like symptoms (like hallucinations and agitation) in people with Lewy Body Dementia. Thirty participants will receive either real or sham stimulation over two weeks. Researc…

This study compares two antipsychotic medications, pimavanserin and quetiapine, to see which one works better for reducing hallucinations and delusions in people with Parkinson's disease or dementia with Lewy bodies. About 94 participants will be randomly assigned to one of the d…

This study is testing whether a non-invasive brain stimulation technique called tACS can improve symptoms like memory and thinking in people with Alzheimer's disease, Lewy body dementia, frontotemporal dementia, and normal pressure hydrocephalus. About 200 participants will recei…

This study uses a special PET scan to measure dopamine production in the brains of people with autonomic failure, including those with Parkinson's disease, Multiple System Atrophy, or Dementia with Lewy Bodies. The goal is to find early signs that predict if a person with pure au…

This study is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of a protein called alpha-synuclein in the brain using PET scans. Researchers will scan 40 people, including those with Parkinson's disease, multiple system atrophy, dementia with Lewy …

This study aims to better predict how dementia will progress in individuals with mild cognitive impairment or early dementia. Researchers will collect blood samples and use computer models to track changes in thinking and memory over time. The goal is to improve prognostic confid…

This study is checking whether people with Lewy body dementia have lower activity of a key brain enzyme called glucocerebrosidase. Researchers will compare enzyme levels in 236 participants (patients and healthy volunteers) to see if a drop in activity is linked to the disease. I…

This study looks at why people with Lewy body dementia (including Parkinson's disease dementia) experience sudden, unpredictable changes in attention and thinking, known as cognitive fluctuations. Researchers will use brain scans, EEG, and thinking tests to measure brain changes …