CUTANEOUS SQUAMOUS CELL CARCINOMA

This study tests a treatment made from a patient's own immune cells (tumor-infiltrating lymphocytes, or TILs) combined with chemotherapy and interleukin-2 for people with advanced skin cancers (cutaneous squamous cell carcinoma or Merkel cell carcinoma) that have not responded to…

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This study tests a drug called ivonescimab in 24 people with advanced cutaneous squamous cell carcinoma that cannot be removed by surgery or has spread. The goal is to see if the drug can help control the cancer and to check for side effects. Participants will receive the drug an…

This early-phase study tests a new drug called tolododekin alfa (ANK-101) for people with advanced solid tumors that have not responded to standard treatments. The drug is injected directly into tumors to see if it is safe and tolerable. About 97 adults with various solid cancers…

This study tests a small adhesive patch with tiny needles that deliver a very low dose of chemotherapy directly into skin cancer tumors. The goal is to see if it is safe and effective at clearing the cancer. About 48 adults with a type of skin cancer called cutaneous squamous cel…

This study tests whether giving two immunotherapy drugs (nivolumab and relatlimab) before surgery can shrink advanced skin cancer (cutaneous squamous cell carcinoma) and lower the chance of it coming back. About 20 adults with stage II to IV cancer that can be surgically removed …

This study tests whether a special 3D ultrasound scan of removed skin cancer tissue can accurately measure if the cancer was fully removed. About 30 adults with a common skin cancer will have their tumor scanned after surgery, and the results will be compared to standard lab test…

This study tests whether adding a special heat treatment (water-filtered infrared-A, or wIRA) to standard palliative radiation can help shrink tumors and ease symptoms in people with advanced head, neck, or skin cancers that cannot be cured. About 60 adults will receive the combi…

This study aims to see if a new predictive model can accurately tell which patients with melanoma and other skin cancers will respond to immunotherapy. Researchers will collect tumor tissue, blood, and stool samples from 1,000 participants and compare the model's predictions to a…

This study looks at 1,500 people with a common skin cancer called cutaneous squamous cell carcinoma. Researchers want to see how well current staging systems predict if the cancer will come back or spread. The goal is to improve how doctors assess risk and manage this cancer.

This study is testing a blood test (liquid biopsy) to see if it can find tiny bits of cancer DNA left behind after surgery for a type of skin cancer called cutaneous squamous cell carcinoma. It will also check if the test can track how well immunotherapy is working. About 60 peop…