CRC

This study is testing whether adding a combination of two common antibiotics (ciprofloxacin and metronidazole) and aspirin to standard chemotherapy helps people with advanced colorectal cancer. Researchers want to see if changing the bacteria in the gut (the microbiome) can make …

This study is testing new combinations of experimental drugs for people with advanced solid tumors that have specific RAS mutations. Researchers want to see if combining a new type of drug called a RAS(ON) inhibitor with another cancer drug called ivonescimab is safe and can help…

This is the first study in people to test a new drug called CBI-1214, which is designed to help the body's own immune cells attack cancer. It is for adults with advanced or metastatic colorectal cancer that has continued to grow despite prior standard treatments. The main goals a…

This study is testing new targeted drugs called RAS inhibitors in combination with standard cancer treatments for people with advanced colorectal or pancreatic cancer. The goal is to find safe and effective doses while seeing if these new drug combinations can help control cancer…

This early-stage study is testing a new drug called RMC-5127 in adults with advanced cancers that have a specific genetic change called KRAS G12V. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with other ca…

This early-stage trial is testing the safety and initial effectiveness of a new drug, HCB101, when added to standard chemotherapy for advanced colorectal cancer. It will involve about 40 adults whose cancer has worsened after first-line treatment. The main goals are to find a saf…

This study is testing a new drug called TUB-030 in adults with advanced solid cancers that have not responded to other treatments. The main goals are to find the safest dose and see if the drug helps control the cancer. It will focus on specific cancers like head and neck cancer …

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This study aims to collect tumor tissue and blood cells from people with advanced solid tumors to prepare for future CAR T-cell therapy. Researchers will analyze the cancer tissue to understand how tumors hide from the immune system and collect participants' own immune cells thro…