CRC
Clinical trials for CRC explained in plain language.
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New combo therapy shows promise for Tough-to-Treat colon cancer
Disease control CompletedThis early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The main goal was to find the safest dose and identify side effects. The study is comple…
Matched conditions: CRC
Phase: PHASE1 • Sponsor: University of California, Irvine • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New drug JAB-21822 targets tough KRAS mutation in advanced cancers
Disease control CompletedThis early-phase trial tested a new oral drug called JAB-21822, alone or with cetuximab, in 29 adults with advanced solid tumors (like lung or colorectal cancer) that have a specific KRAS G12C mutation. The main goals were to check safety and find the right dose. Participants had…
Matched conditions: CRC
Phase: PHASE1, PHASE2 • Sponsor: Jacobio Pharmaceuticals Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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New targeted drug shows promise for BRAF-Mutant cancers in early trial
Disease control CompletedThis early-stage trial tested a new drug called CFT1946, alone or with other drugs, in 89 adults with solid tumors that have a BRAF V600 mutation, including melanoma, lung, colon, and thyroid cancers. The main goals were to check safety and find the best dose. The study is comple…
Matched conditions: CRC
Phase: PHASE1 • Sponsor: C4 Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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New biopsy method may predict cancer spread without surgery
Knowledge-focused CompletedThis study looked at 150 colorectal cancer patients to see if counting tumor buds in biopsy samples could predict whether cancer has spread to lymph nodes or other organs. Researchers used a special stain to find tumor buds and counted them in the densest area. They then used a c…
Matched conditions: CRC
Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC