CHILDHOOD CANCER

This study offers girls and young teens facing strong cancer treatments the chance to freeze a piece of their ovary before therapy begins. The goal is to help preserve their ability to have biological children later in life. Around 100 participants will undergo a safe procedure t…

This study is testing a chemotherapy plan specially designed for children with Down syndrome who have a new diagnosis of acute lymphoblastic leukemia (ALL). The treatment uses lower doses of certain drugs to reduce side effects while still fighting the cancer. About 60 children a…

This pilot study looks at whether a home exercise program plus a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adult survivors of childhood cancer who have prediabetes. The study will enroll 20 people a…

This study tests whether sending personalized print materials and a follow-up phone call can encourage women who had childhood cancer to get mammograms. Participants are 360 women aged 25-49 who received chest radiation as children and haven't had a mammogram in two years. The go…

This study tests whether children and teens with cancer will stick with a personalized exercise program during their treatment. About 38 participants will be offered adapted physical activity sessions from diagnosis or relapse. Researchers will use questionnaires to find out what…

This study tests two short-term drug regimens—dasatinib plus quercetin, or fisetin alone—in 110 adult survivors of childhood cancer who are frail. The goal is to see if these 'senolytic' drugs can clear aging cells, improve walking speed, and reduce frailty. It is a first-of-its-…

This study looks at whether different levels of exercise can improve heart health in young adults who survived childhood cancer and were treated with a type of chemotherapy called anthracyclines, which can weaken the heart. Twenty survivors aged 18 to 39 will do either high-inten…

This study tests whether a game-based exercise plan can increase physical activity in childhood cancer survivors aged 10 to 16. The child and a parent or caregiver both take part in the program. Researchers will also see if the plan improves the child's quality of life. The goal …

This study looks at whether a daily mindfulness app called Headspace can help adults who survived childhood cancer cope with stress. Fifty survivors will use the app for 30 days and wear a wrist device to track stress signs. The main goal is to see if people find the app acceptab…

This study tests whether using a kaleidoscope can reduce pain, anxiety, and fear in children aged 6-14 with cancer who are getting subcutaneous injections. The kaleidoscope is used as a distraction during the procedure. The study involves 72 children and compares their pain and f…

This study asks 10 young adult survivors of childhood cancer to watch exercise videos and share their thoughts. The goal is to adapt the videos so they feel more relatable and useful for other survivors. Researchers will use interviews and a questionnaire to understand what works…

This pilot study looks at whether adult survivors of childhood cancer will take part in two health programs at the same time. Participants will either do exercise plus cognitive training (brain games) or exercise plus mindfulness practice over 12 weeks. The goal is to see if peop…

This study is developing a patient-reported survey to better capture symptoms in adults who survived childhood cancer. Researchers will work with 837 survivors to identify which symptoms matter most and create a validated tool. The goal is to improve long-term follow-up care by m…

This study looks at how tiredness (fatigue) affects the daily activities and quality of life of 89 children aged 2 to 18 who are being treated for cancer. Researchers will use special surveys to measure fatigue levels and see how they relate to the children's ability to do everyd…

This study follows 50 young men who had cancer or blood disorders as children and received treatments that can harm fertility. Some stored testicular tissue before treatment; others did not. Researchers will check their fertility through exams, ultrasounds, blood tests, and semen…

This study was designed to understand heart rate and sleep issues in adults who survived childhood cancer. Researchers planned to use a smartphone app and wearable device to compare survivors with their siblings. The goal was to identify who is most at risk and develop ways to pr…

This study looks at whether data from smartphones and wearable devices can help predict future health problems in adults who survived childhood cancer. About 600 survivors will track symptoms, activity, sleep, and heart rate. The goal is to use this information to improve follow-…

This study looks at how cancer treatment changes the social lives of adolescents and young adults aged 15 to 22. Researchers will survey patients on and off therapy about their friendships, loneliness, and family relationships. The goal is to understand their social needs and gui…

This study looks at whether a smartwatch ECG can predict heart muscle disease (cardiomyopathy) in adult survivors of childhood cancer as well as a standard clinic ECG does. About 1,300 survivors will have both a standard 12-lead ECG and a 30-second Apple Smartwatch ECG. The goal …

This study tests a digital self-management and peer mentoring program for young adults who survived childhood cancer. The goal is to help them take charge of their own health care as they move from pediatric to adult clinics. About 300 survivors aged 18-25 will use the program to…

This study aimed to see if adult survivors of childhood cancer could use wearable devices, surveys, and lab tests at home to monitor their heart health. It was designed for survivors who had certain cancer treatments. However, the study was withdrawn before enrolling any particip…

This study follows 62 children and teens in Ecuador who have finished cancer treatment. Researchers will check how well they follow six healthy lifestyle habits—like eating well, sleeping enough, and staying active—and see if those habits are linked to better quality of life and …

This study looks at dental and jaw problems in children who had proton beam therapy for head and neck cancer. Researchers will survey survivors and review dental records to see how often these side effects occur and how they relate to radiation dose. The goal is to gather informa…

This study aimed to find early markers of heart damage in children with cancer who receive a type of chemotherapy called anthracyclines. Researchers planned to use blood tests and heart scans to identify which children were at highest risk. However, the study was withdrawn before…