BIPOLAR II DISORDER

This study is testing whether a strict 16-week ketogenic diet (low carbs, high fat, medium protein) can help teens aged 12–21 with bipolar disorder feel better and improve their metabolic health. Eighty participants will receive the diet along with their usual medication and regu…

This study compares two common mood stabilizers—lithium and lamotrigine—in 200 adults with bipolar II disorder. Over six months, participants will track their daily mood using a smartphone app to see which drug provides better mood stability. The goal is to find out which treatme…

This study aims to find the best weight-loss medication for people with bipolar disorder by identifying their obesity type—such as 'hungry brain' or 'hungry gut.' About 100 adults aged 18-65 with bipolar or schizoaffective disorder will be assigned one of three FDA-approved drugs…

This pilot study tests whether time-restricted eating (eating all food within a 10-hour window each day) is feasible and acceptable for people with bipolar disorder. 40 participants will either follow the eating schedule or receive nutritional counseling for 8 weeks. The goal is …

This study tests an experimental drug called icalcaprant for treating depression in people with bipolar I or II disorder. About 195 adults will take either the drug or a placebo daily for 6 weeks. Researchers will measure changes in depression symptoms and watch for side effects.

This study is testing the safety and tolerability of an experimental drug called ABBV-932 for people with bipolar I or II disorder who are currently in a depressive episode. About 200 adults will take the drug as capsules for 26 weeks, with regular check-ups and tests to monitor …

This study tests a program called 'Need to be Needed' for adults with serious mental illness who feel lonely or isolated. Over 6 months, participants in the program will work with a coach to set goals and do acts of kindness, like volunteering. The goal is to see if helping other…

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help people with bipolar disorder feel better. About 150 adults who are already on medication for bipolar disorder will track their eating, sleep, and mood for 2 weeks, then follo…

This study tests whether customizing the electrical dose of ECT (electroconvulsive therapy) can better treat depression and cause fewer memory problems in older adults. Fifty people with depression who are scheduled for ECT will receive either a standard or a personalized dose. R…

This study tests an experimental drug called azetukalner for people with bipolar I or II disorder who are currently in a depressive episode. About 400 adults will receive either the drug or a placebo for 6 weeks. The main goal is to see if the drug reduces depression symptoms bet…

This study tracks up to 1,260 people aged 8 to 60 with or without mood disorders like bipolar disorder or major depression. Over two years, participants wear activity monitors, light sensors, and complete daily smartphone diaries about mood, sleep, and activities. The goal is to …

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their lifetime experiences with conditions like depression, …

This study follows 80 youth aged 9 to 19 with bipolar disorder across four U.S. sites. Researchers will track mood symptoms, inflammation, and family conflict over 12 months to find what predicts better or worse outcomes. The goal is to create standardized tools and best-practice…