BIPOLAR II DISORDER

This study looked at whether repeated ketamine infusions can help people with hard-to-treat bipolar depression stay well. 41 adults who had already responded to an initial course of ketamine received up to 6 more infusions over 12 weeks. The goal was to see if maintenance doses c…

This Phase 2 trial tested whether four intravenous ketamine infusions over two weeks could safely and quickly reduce depression in 71 adults with treatment-resistant bipolar disorder. Participants received either ketamine or a sedative (midazolam) as a comparison. The study measu…

This study tested an experimental drug called ABBV-932 in 161 adults with bipolar I or II disorder who were currently experiencing a depressive episode. Participants took either the drug or a placebo daily for 6 weeks. The goal was to see if the drug safely reduces depression sym…

This study tested whether esketamine, a fast-acting antidepressant, works as well as electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression or bipolar disorder. 340 adults received either esketamine infusions or ECT over two weeks. The ma…

This study tested an investigational medication called BXCL501 for calming agitation episodes in people with schizophrenia or bipolar disorder. The medication was designed to be taken at home. 452 adults took part, and the drug was compared to a placebo (a dummy pill). The goal w…

This early-stage study tested a new oral drug, SEP-380135, in 43 adults with schizophrenia or major depression (including bipolar disorder). The main goal was to check its safety and how the body processes it. Participants took multiple doses and were monitored for side effects, …

This study looked at how well people with bipolar I and bipolar II disorder recognize facial emotions compared to healthy individuals. Ten participants completed a facial emotion recognition test and questionnaires. The goal was to see if there are differences between the two bip…

This study followed 300 pregnant women to understand why some develop mood disorders like depression or bipolar episodes after giving birth. Researchers collected genetic, hormonal, and environmental data to find patterns that could predict these episodes. The goal is to better i…

This study looked at how well patients, their family members, and doctors agree when rating agitation episodes in people with bipolar disorder or schizophrenia. Thirty-three adults received a treatment called BXCL501, and researchers compared different questionnaires to see which…