ALS (AMYOTROPHIC LATERAL SCLEROSIS)

This study is testing a new approach for people with motor neuron disease (ALS) that combines a non-invasive brain stimulation technique called rTMS with mixed reality exercise games. The goal is to slow down the disease and improve quality of life. The trial will involve 100 par…

This study tests whether a probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking probiotics to those taking a placebo over 24 weeks. The goal is to see if probiotics affect di…

This early-stage study tests a single dose of the gene therapy CTx1000 in 15 people with ALS (Lou Gehrig's disease). The main goal is to see if the treatment is safe and tolerable, not to cure the disease. Participants must have been diagnosed within the last 2 years and be on st…

This program offers SPG302, an experimental drug, to adults with ALS who cannot join other clinical trials. The goal is to check if the drug is safe and can help slow the disease. Participants must have a confirmed ALS diagnosis and be between 18 and 80 years old.

This early study is testing a device called a brain-computer interface that is implanted into a blood vessel in the brain. It is designed to help people with ALS who have weakness in both arms control external devices, like a computer, using only their thoughts. The study will in…

This early-stage study tests a new drug called LY4256984 in 32 people with ALS. The drug is given as a shot into the spine to see if it is safe and what side effects it may cause. Researchers will also measure how much drug gets into the blood and spinal fluid. This study does no…

This study tests whether tofersen, a drug already approved for a specific genetic form of ALS, can help people with ALS who do not have that gene mutation. About 30 adults will receive the drug via spinal injections over 24 weeks. Researchers will measure nerve damage markers, sa…

This study tests a non-invasive device called MyoRegulator® in 15 people with ALS. The device uses mild electrical stimulation to calm overactive motor neurons, which may help slow disease progression. The goal is to check safety and gather early signs of effectiveness before a l…

This study tests a powered neck exoskeleton in 10 people with ALS who have neck weakness. Participants wear the device and perform tasks like tracking on a screen and daily activities to see if it improves head movement and is comfortable. The goal is to find out if the device ca…

This study tests a tongue exercise program for people with ALS to see if it can help maintain speech and swallowing. Twenty participants will practice pressing their tongue against a device five days a week for five weeks, with support from a speech therapist. Researchers will me…

This study is testing a special fabric shoulder brace that mimics muscle action to help people with neuromuscular disorders (like muscular dystrophy or ALS) move their arms better. About 30 participants will be evaluated with and without the brace to see if it improves reach, str…

This study aims to find new biological markers for diseases like Alzheimer's, Parkinson's, and ALS by analyzing the genes, proteins, and metabolism of 1,200 patients. Researchers will use advanced technology to look for patterns that could help with earlier diagnosis, better prog…

This study is following 2950 people, including healthy individuals and those with memory or movement problems, to learn more about brain diseases like Alzheimer's and Parkinson's. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve di…

This study is creating a standard test to measure how well assistive technologies (ATs) and brain-computer interfaces (BCIs) help people with spinal cord injury or ALS use computers and phones. About 60 participants, including healthy volunteers and people with motor impairments,…

This study is creating a national registry of 100 people with ALS in Thailand. Researchers will track their health, genetics, and survival over time to better understand the disease. The goal is to gather information that can support future research and treatments.

This study looks back at the past 10 years to understand how many people in Denmark use a breathing machine at home through a tube in their windpipe. Researchers will track which diseases lead to this need, such as ALS or spinal cord injury, and how many patients survive one year…

This study aims to find biological markers (biosignatures) in body fluids and tissues that can help doctors diagnose ALS and FTD more accurately and earlier. Researchers will analyze samples from 230 adults using advanced techniques to detect abnormal proteins and other changes. …

This study uses a new, ultra-detailed PET scanner to see very small brain structures in healthy aging and in conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. Researchers will scan 300 volunteers and patients to find early signs of disease and create detaile…