New device aims to tame overactive nerves in ALS

NCT ID NCT06649955

Recruiting now Disease control Sponsor: PathMaker Neurosystems Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests a device called MyoRegulator® that uses mild electrical currents to calm overactive motor neurons in people with ALS. The goal is to see if it is safe and feasible, and whether it might slow disease progression. Fifteen participants will receive the treatment and be followed for several months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MyoRegulator® device (multi-site direct current stimulation)
What this could lead to: If it works, this could point toward a new way to slow ALS progression by calming overactive motor neurons.
What could go wrong: This is a very small, early feasibility study with only 15 people. It is not yet proven to work, and the device may not show meaningful benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALS (AMYOTROPHIC LATERAL SCLEROSIS)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

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