ALS - AMYOTROPHIC LATERAL SCLEROSIS

This study tests a fully wireless brain-computer interface (BCI) that aims to decode attempted speech in real time for people with locked-in syndrome (LIS), often caused by ALS or stroke. The implant records brain signals from areas controlling the mouth and throat, then translat…

This study tests whether a nasal spray called foralumab is safe and tolerable for people with ALS, a disease that damages nerve cells controlling movement. Foralumab is designed to calm inflammation and immune activity thought to contribute to ALS. About 44 adults aged 18 to 75 w…

This early-phase trial tests an oral drug, Kamlanoflast, in 40 people with ALS. Over 24 weeks, researchers will check safety, tolerability, and whether the drug reduces inflammation and slows decline in function. It is not yet recruiting.

This study tests whether combining two drugs (galunisertib and nerandomilast) can slow the progression of ALS in 60 people who have high levels of a protein called GREM2. The drugs aim to reduce brain inflammation and nerve cell damage. Participants will receive either the drug c…

This study aims to find specific markers in blood platelets that can help doctors diagnose ALS (Lou Gehrig's disease) more accurately and earlier. Researchers will compare 60 participants—30 with newly diagnosed ALS and 30 with other motor neuron diseases—to see if platelet tests…

This study tests whether a home-based virtual reality guided breathing program can reduce anxiety and improve quality of life in people with ALS. Sixty participants will use a VR headset to follow breathing exercises. The goal is to see if this simple, immersive tool can help man…

This study will test a new device that combines a brain-sensing headband with Apple's Vision Pro goggles to help people with ALS, brain injury, or spinal cord injury communicate. Up to 10 participants will use the system for 3-4 months to see how well they can type and control a …

ALS is a progressive nerve disease with no simple test for early diagnosis or tracking. This study is collecting blood samples and medical data from 200 people with ALS to look for patterns in proteins, genes, and immune markers. The goal is to build a biomarker panel that could …

This observational study screens 500 people with early-stage ALS to see if they qualify for specific early-phase clinical trials. Participants undergo tests, genetic analysis, and biomarker checks to match them with the right trial. The study also builds a research database for f…