ALS (AMYOTROPHIC LATERAL SCLEROSIS)

This study is testing whether combining two drugs, galunisertib and nerandomilast, can slow the progression of ALS in patients who have a specific biomarker called GREM2. The drugs aim to reduce harmful inflammation and scarring in the nervous system. The trial will enroll 60 adu…

This early-stage study is testing a new oral drug called Kamlanoflast in 40 people with ALS (amyotrophic lateral sclerosis). The main goals are to check if the drug is safe and tolerable when taken for 24 weeks, and to see how it affects markers of inflammation and physical funct…

This study aims to find a faster way to diagnose ALS (amyotrophic lateral sclerosis) by looking for specific markers in blood platelets. Researchers will compare blood samples from 60 people recently diagnosed with ALS to those with other similar nerve diseases. The goal is to id…

This study is testing whether simple, at-home virtual reality (VR) breathing exercises can help reduce anxiety and improve quality of life for people living with ALS. Researchers will enroll 60 participants across five Canadian sites, randomly assigning them to either use the VR …

This study is testing a 5-week tongue exercise program to see if it can help people with ALS swallow more safely and speak more clearly. All 20 participants will do the exercises at home and have weekly video check-ins with a speech therapist. Researchers will measure changes in …

This study aims to understand how the use of home mechanical breathing machines has changed in Denmark over the past 10 years. Researchers will look at data from about 450 patients with conditions like ALS or spinal cord injuries who needed this type of long-term breathing suppor…

This study aims to identify people with ALS who might qualify for early-stage clinical trials. Participants will undergo health assessments and provide blood samples to check if they match specific trial requirements. The research also creates a database of genetic and health inf…

This study aims to test and improve a new communication device for people who have lost the ability to speak or type due to conditions like ALS, stroke, or spinal cord injury. Up to 10 participants will use an augmented reality headset that can detect brain signals and eye moveme…