Viral infection of central nervous system

Researchers are testing whether a new oral polio vaccine called nOPV2, given at birth, helps infants block type 2 poliovirus in their intestines. The trial enrolls 740 healthy newborns who have received standard injected polio vaccines. Scientists will check stool samples for sig…

This study tests a new oral polio vaccine (nOPV3) in healthy young children, infants, and newborns in Panama. The goal is to see if it is safe and triggers a strong immune response compared to the current vaccine. About 1,500 participants will receive either the new or existing v…

This study tests two types of inactivated polio vaccine (Sabin strain and wild strain) given in different orders to 480 infants aged 2 months. The goal is to see which sequence triggers the best immune response and causes the fewest side effects. Participants will receive three d…

This phase 4 study compares a single dose of an inactivated polio vaccine (sIPV) in people aged 7 to 50 years with the standard three-dose series given to infants. Researchers want to see if one shot can produce a similar immune response. The trial is recruiting 180 healthy parti…

This study tests a new oral polio vaccine (nOPV1) in over 2,200 healthy young children, infants, and newborns in Bangladesh. Researchers will compare it to the current Sabin vaccine to see if it is safe and triggers a strong immune response. The goal is to find a more stable vacc…

This study tests whether giving two new oral polio vaccines (types 1 and 2) together is safe and works as well as giving them separately in healthy 16-week-old infants. About 675 babies in Panama will receive either the combo or single vaccines. The goal is to see if the combo ap…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests whether the steroid dexamethasone can reduce brain damage in adults hospitalized with tick-borne encephalitis. Researchers will compare disability outcomes in 200 patients who receive either dexamethasone or a placebo. The goal is to see if this treatment lowers …

This study is testing whether immune checkpoint inhibitors, drugs that help the immune system fight infections, can improve outcomes for people with progressive multifocal leukoencephalopathy (PML), a rare brain virus. Researchers will follow 66 patients over a year, measuring di…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, SMA, and muscular dystrophy exercise safely. Because these conditions weaken the nerves that control muscles, traditional exercise is often too hard. W…

This study is a registry that collects information from 520 patients diagnosed with central nervous system (CNS) infections, such as meningitis or encephalitis. Researchers will track how many patients survive to discharge. The goal is to better understand these rare but serious …

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study follows 209 children and adults hospitalized with tick-borne encephalitis (TBE) in the Czech Republic for one year after discharge. Researchers track symptoms like fatigue, headaches, memory problems, and weakness to see how long they last and who needs extra support. …

This study surveys 100 doctors and trainees in France to assess their knowledge of tick-borne encephalitis, a rare but serious viral infection spread by ticks. The goal is to see if doctors in high-risk areas are more aware than those elsewhere, and to identify gaps that could im…

This study follows 3,000 childhood cancer survivors in Switzerland to learn about long-term health problems caused by cancer treatments. Participants undergo physical exams, lab tests, and questionnaires during regular follow-up visits. The goal is to better understand and manage…