Univentricular heart

This study tests whether a high-calorie formula called Fortini helps babies born with a serious heart condition (single ventricle) grow better after their first heart surgery. About 100 infants will be randomly assigned to receive either Fortini or standard high-calorie formula a…

This study tests whether a home-based digital exercise program can increase physical activity and fitness in children aged 10-17 with Fontan circulation, a heart condition. Participants will wear an activity tracker for 12 months and complete fitness tests. The goal is to see if …

This early-stage trial tests whether heart cells grown from a patient's own stem cells are safe to inject into people with severe congenital heart disease. About 50 participants will receive the cells or be in a control group. The main goal is to check for serious side effects wi…

This study tests whether injecting a child's own heart stem cells (JRM-001) after reconstructive surgery can improve heart function in children with single ventricle heart defects. About 40 children scheduled for Glenn or Fontan surgery will receive either the stem cells or a pla…

This study tests whether wearing compression garments on the legs can increase the amount of blood the heart pumps during exercise in adults with Fontan circulation. Twenty participants will undergo exercise tests with and without the garments, and a subset will wear them for two…

This study tests whether live, group exercise sessions delivered via video chat can improve fitness in teens (ages 12-19) with certain types of congenital heart disease. 74 participants will either join the remote exercise program or receive standard exercise handouts. The main g…

This study tests whether a cardiac rehabilitation program can help adults with Fontan failure walk more each day and improve their exercise ability, frailty, and quality of life. Researchers will compare the rehab group to those receiving usual care. The trial aims to enroll 50 p…

This study tests a new pulse oximeter worn on the abdomen, designed to measure oxygen levels in infants with congenital heart disease. Researchers compare its accuracy against standard fingertip monitors and direct blood measurements. The device also includes features to reduce e…

This study compares using ultrasound versus an age-based formula to choose the correct breathing tube size for children aged 3 months to 8 years with single ventricle heart conditions. The goal is to see which method leads to fewer breathing tube placement attempts and less post-…

This study follows 52 children with cyanotic congenital heart disease and a single working heart chamber (univentricular heart) who undergo a series of surgeries ending with the Fontan procedure. Researchers will compare outcomes like survival, complications, and quality of life …

This study will collect leftover blood samples from 10 newborns with severe heart defects who have surgery at Boston Children's Hospital. Researchers want to understand why these babies are more likely to develop dangerous blood clots after surgery. They will look at tiny molecul…

This international registry is tracking 400 adults with congenital heart disease who are taking SGLT2 inhibitors, a type of diabetes medication that also benefits the heart. Researchers want to see how these drugs are being prescribed, how well they are tolerated, and whether the…

This study tests a new 3D ultrasound technique (Ventripoint) to see if it can accurately measure heart size and function in children and young adults born with a single ventricle. Researchers will compare the 3D ultrasound to standard echocardiograms and cardiac MRIs. The goal is…