Tricuspid valve insufficiency

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks. The device is implanted in the veins to help blood flow better. About 780 participants will be randomly assigned to get the device plus standard medic…

This study tests a new device called the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System for people with severe tricuspid regurgitation, a condition where the heart's tricuspid valve leaks blood backward. The device is placed through a catheter, avoiding open-hear…

This study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…

This study tests a step-by-step treatment plan for people with a narrowed aortic valve who also have leaky mitral or tricuspid valves. After a minimally invasive procedure to fix the aortic valve, doctors will check if the other valves still leak badly. If so, additional procedur…

This study tests a new device called the TRiCares Topaz, which replaces the tricuspid heart valve without open surgery. It is for people with severe tricuspid regurgitation (a leaky valve) who still have symptoms despite medication. The study will compare this device to another a…

This early study tests a new device called the TRICENTO G2 to treat severe tricuspid regurgitation, a condition where a heart valve leaks badly. Ten adults with symptoms like shortness of breath or swelling will get the valve through a minimally invasive procedure. The goal is to…

This study tests whether setting a pacemaker to a faster rate (90 beats per minute) can help people with right heart failure and severe tricuspid regurgitation. Twenty-four participants with a low resting heart rate will get a special pacemaker implant and be followed for 6 month…

This study will enroll 404 people with severe leakage in both the mitral and tricuspid heart valves. Participants will be randomly assigned to have either both valves repaired at once using a catheter-based device, or only the mitral valve repaired. The goal is to see which appro…

This study tests a new device called the MIA-T system, which is inserted through a catheter to repair the tricuspid valve in people with severe leakage. The trial will enroll 600 patients who are too high-risk for traditional surgery. The goal is to see if the device safely impro…

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This study tests whether placing soft foam dressings on the skin before heart surgery can prevent pressure injuries (bedsores). About 80 adults having long heart surgeries will be enrolled. Researchers will check for new skin injuries after surgery and track how severe they are. …

This study tests whether the TriClip device, which repairs a leaky tricuspid valve without open surgery, can improve daily life for people with severe tricuspid regurgitation. 150 participants will be randomly assigned to receive either the TriClip or a placebo procedure. The mai…

This study compares two sedatives, remimazolam and midazolam, to see which one causes less confusion (delirium) after heart valve surgery in people aged 65 and older. Delirium affects up to 70% of older heart surgery patients and can lead to longer hospital stays and memory probl…

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This study will compare two newer pacemaker technologies—left bundle branch area pacing and leadless pacing—to see how they affect heart function and the tricuspid valve. Twenty adults with certain heart block conditions will receive both types temporarily during their routine pa…

This study will follow 5,500 people in China who receive new heart valve devices (replacement or repair) for conditions like aortic stenosis or mitral regurgitation. Researchers will track safety issues such as stroke, bleeding, and device function over time. The goal is to see h…

This study will test a new ultrasound catheter called VeriSight Pro that takes pictures from inside the heart. Doctors will use it during procedures like closing a hole in the heart or fixing a valve. The goal is to see if it helps guide these procedures safely and effectively. A…

This observational study will follow 50 people with severe tricuspid regurgitation (a leaky heart valve) and reduced heart function who undergo valve repair using the PASCAL Precision System. The main goal is to see if, 12 months after repair, patients can take higher doses of st…

This study tests a special catheter that measures how well the right side of the heart is working in 8 people with severe tricuspid regurgitation (a leaky heart valve). Participants are already scheduled for a procedure to fix the valve. The goal is to see if this tool can help d…

This pilot study will follow 90 men aged 18-50 who need heart surgery, some of whom will take the blood thinner warfarin afterward. Researchers will track changes in sperm count, movement, shape, DNA health, and hormone levels over 12 months. The goal is to see if warfarin harms …

This study will collect information from 15 patients in Asia-Pacific who have had or will have a less invasive procedure to fix a failed mitral or tricuspid heart valve. The goal is to learn how well these procedures work in this population, since most existing data comes from We…

This study will measure a specific heart function index in 2,640 healthy adults and people with heart conditions using AI-enhanced 3D ultrasound. The goal is to establish normal ranges and see how this measurement changes in diseases like heart failure and high blood pressure in …