Spastic cerebral palsy

This study tests whether a child's own bone marrow stem cells can safely improve movement and muscle control in cerebral palsy caused by lack of oxygen at birth. Fifty-eight children aged 1 to 10 will be split into two groups: one gets stem cell infusions right away, the other wa…

Researchers at the University of Washington are testing whether non-invasive spinal stimulation can temporarily reduce muscle stiffness and improve walking in people with cerebral palsy. The study includes 20 participants aged 4 to 65 who can walk for at least 10 minutes. Partici…

This trial tests whether a home-based system combining a humanoid robot with virtual reality games can improve arm function in children with cerebral palsy. About 60% of these children have impaired arm use, and doing enough daily exercises is often boring and hard to stick with.…

This trial tests whether delivering electrical pulses to spinal nerves can temporarily calm spastic muscles in children with cerebral palsy. Researchers will stimulate the dorsal root nerves during a planned surgery and measure muscle responses. The goal is to see if this stimula…

This study tests a therapy called HABIT-ILE, which uses structured hand and leg exercises, to see if it can improve both motor skills and cognitive functions like memory and attention in children with spastic cerebral palsy. 42 children will receive 90 hours of therapy and be com…

This study looks at whether a 10-week plan with a leucine supplement is practical for children with spastic cerebral palsy. It also checks for early signs of muscle growth using ultrasound. Only 5 children will take part to see if they can stick with the supplement and if it affe…

This study tests whether adding task-specific electrical stimulation to standard physical therapy can improve upper limb gross motor skills in children aged 2 to 6 with spastic quadriplegia cerebral palsy. Thirty children will be split into two groups: one gets standard therapy, …

This study looks at whether adding a single session of whole-body vibration to treadmill training can improve walking and reduce muscle stiffness in children with cerebral palsy. About 20 kids aged 6-17 who can walk will participate. The goal is to see if combining these therapie…

This small safety trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can safely improve hand and arm function in 10 adolescents with spastic cerebral palsy. Participants will use the device during upper limb rehabilitation sessions. The main…

This study tests two new methods to improve hand function in children with cerebral palsy: a virtual reality system called Leap Motion that uses hand-tracking games, and neuromuscular electrical stimulation (NMES) that uses mild electrical pulses to activate muscles. Thirty child…

This study tests whether a 12-week functional power training program (MegaPower) helps children with cerebral palsy achieve their personal participation and activity goals better than usual care. The trial will include 66 children aged 4-12 who can walk with or without help. Rese…

This study tests a treatment that uses precise radiation beams to target nerves in the back, aiming to reduce muscle tightness (spasticity) caused by stroke, spinal cord injury, or cerebral palsy. About 22 people will be randomly assigned to receive either the real treatment or a…

This study tests a 10-week hand strength training program for 14 children aged 6-12 with spastic cerebral palsy. The goal is to see if it improves their grip strength and ability to manipulate objects in their hand. Researchers will measure changes using a dynamometer and the Mel…

This study looks at how muscles grow and change in children with cerebral palsy (CP) by examining tiny samples from leg muscles. Researchers will compare these microscopic findings with muscle images and movement tests. The goal is to better understand why muscles in CP develop d…

This study looks at muscle problems, metabolic issues, and chronic inflammation in adolescents and young adults (ages 14-30) with moderate to severe spastic cerebral palsy. Researchers will compare them to less affected and healthy peers, then have the more affected group do a 12…

This study looks at how botulinum toxin (Botox) injections change muscle structure in children with spastic cerebral palsy. Using advanced imaging like MRI and 3D ultrasound, researchers will measure muscle size, fat content, and stiffness in 51 children. The goal is to understan…

This study looks at how ankle-foot orthoses (AFOs) change the way leg muscles work in 30 children with cerebral palsy (ages 6–17). Researchers will measure muscle activity while children walk barefoot and with their prescribed AFO, both on a treadmill and overground. The goal is …

This study aims to understand how muscles change over time in children with spastic cerebral palsy. Researchers will use 3D ultrasound to measure muscle size, length, and quality in 229 children. The goal is to link these changes to brain injury and treatments, helping improve fu…

This study looks at children with spastic cerebral palsy to see if ultrasound images of their muscles can predict how well they can move. Researchers will measure muscle thickness, stiffness, and blood flow, and compare these to standard tests of motor function. The goal is to fi…