Severe pre-eclampsia

This study looks at whether giving enalapril, a standard blood pressure medicine, to women who had preeclampsia during pregnancy can help control their blood pressure after childbirth. Researchers will enroll 60 postpartum women and randomly assign them to enalapril or usual care…

This pilot trial tests whether using placental tissue analysis from a prior complicated pregnancy can guide treatment with the blood thinner enoxaparin to reduce the risk of recurrent adverse outcomes. The study enrolls women who had a previous pregnancy affected by early deliver…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This study tests whether MitoQ, a mitochondrial antioxidant, can improve blood vessel function and placental health in pregnant people with severe preeclampsia. Researchers will measure blood flow in the arm, skin, and placenta to see if MitoQ helps restore normal function and pr…

This Phase 2 trial tests ravulizumab (Ultomiris) in 14 pregnant individuals with severe preeclampsia or HELLP syndrome before 34 weeks of pregnancy. The drug aims to block part of the immune system that may drive these dangerous conditions. Researchers will measure blood markers …

This study tests a cloud-connected blood pressure monitoring program for new mothers with high blood pressure disorders. The goal is to see if remote monitoring helps more women track their blood pressure after giving birth and reduces hospital readmissions. About 540 pregnant an…

This study is testing whether taking a low-dose aspirin (81 mg) daily for three weeks after giving birth can improve blood vessel function in women who had severe preeclampsia. About 100 women will be randomly assigned to receive either aspirin or a placebo. The main goal is to s…

This study tests whether lung ultrasound can detect fluid overload in women with severe preeclampsia, a condition that can lead to life-threatening pulmonary edema. Researchers will scan the lungs of 202 pregnant women at three key times: upon admission, right after delivery, and…

This trial tests whether starting intensive blood pressure medication soon after childbirth can prevent chronic hypertension in women who had preeclampsia. Participants are randomly assigned to receive nifedipine ER when their blood pressure reaches different thresholds during th…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study aims to understand how tiny particles called exosomes, released from the placenta, may cause preeclampsia—a serious pregnancy condition involving high blood pressure. Researchers will collect blood and placenta samples from 64 women with preeclampsia and study these pa…

This study follows 462 women pregnant after egg donation or standard IVF to learn why pre-eclampsia is more common in egg donation pregnancies. Participants give blood samples and have regular check-ups throughout pregnancy. The goal is to find early warning signs and improve car…

This study looks at how often the diaphragm — the main muscle used for breathing — becomes weak after a C-section in women with severe preeclampsia. Researchers will use ultrasound to measure diaphragm movement before and 24 hours after surgery in 52 women. The goal is to find ou…

This study looks at whether tiny particles from blood vessels, found in urine, can help predict which pregnant women with high blood pressure will develop a dangerous condition called pre-eclampsia. Researchers will measure these particles in 110 pregnant women at two points duri…

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy. Researchers will measure blood vessel stiffness and collect blood samples for a biobank. The goal is to better understand long-term heart and kidney health after these conditio…