Severe pre-eclampsia
MONDO:0001641Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.
Also known as: Preeclampsia with severe features, severe preeclampsia
51 clinical trials for this condition and its sub-types.
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Broader categories
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Could vinegar and fasting fix prediabetes cholesterol?
Disease control CompletedThis study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…
Phase: NA • Sponsor: University of Lahore • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Which IV drug tames severe preeclampsia better? labetalol vs hydralazine
Disease control CompletedThis completed study compared two intravenous blood pressure medications, labetalol and hydralazine, in 132 pregnant women with severe preeclampsia. The goal was to see which drug more effectively lowered blood pressure to safe levels. Results could help doctors in the local sett…
Phase: NA • Sponsor: Muhammad Aamir Latif • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New program helps new moms control blood pressure at home
Disease control CompletedThis study tested a program for women with high blood pressure after pregnancy. Participants monitored their blood pressure at home and reported it through an app. A nurse navigator helped adjust medications and coordinated follow-up care. The goal was to improve blood pressure c…
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Which blood pressure drug better protects kidneys in severe pre-eclampsia?
Disease control CompletedThis study looked at 170 women with severe pre-eclampsia in the ICU to see which blood pressure drug—phentolamine or glyceryl trinitrate (GTN)—better protects kidney function. Pre-eclampsia can harm the kidneys, and GTN has been linked to kidney injury in some cases. The research…
Phase: PHASE4 • Sponsor: Assiut University • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Simple ultrasound test may spot kidney risk in preeclampsia patients
Diagnosis CompletedThis study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…
Sponsor: Cairo University • Aim: Diagnosis
Last updated Jun 27, 2026 13:00 UTC
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New study: common painkillers may be safe for new moms with severe preeclampsia
Symptom relief CompletedThis study looked at whether adding nonsteroidal anti-inflammatory drugs (NSAIDs) to standard pain relief is safe for women with severe preeclampsia after giving birth. 287 women participated, and researchers measured their blood pressure and need for blood pressure medication. T…
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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App aims to ease postpartum hypertension and depression
Symptom relief CompletedThis study tested a self-management app for women who had high blood pressure during pregnancy. 99 new mothers used the app to track their blood pressure, stress, and mood, or received usual care. The goal was to see if the app helps lower blood pressure and improve mental health…
Phase: NA • Sponsor: National Cheng-Kung University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Gut check: could your microbiome predict pregnancy danger?
Knowledge-focused CompletedThis study looks at whether substances produced by gut bacteria, called TMAO, can help predict high blood pressure during pregnancy. Researchers will track 200 pregnant women by collecting blood and urine samples throughout their pregnancies. The goal is to find early warning sig…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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Could a simple blood test predict severe preeclampsia?
Knowledge-focused CompletedThis study looks at whether a blood gas measurement called base excess differs between pregnant women with severe preeclampsia and those with normal blood pressure. Researchers will test 100 women before delivery to see if abnormal base excess levels are linked to more severe dis…
Phase: NA • Sponsor: Saint Thomas Hospital, Panama • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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HELLP syndrome blood markers tracked daily in new study
Knowledge-focused CompletedThis completed study observed 72 pregnant women with HELLP syndrome in the ICU. Researchers tracked daily changes in platelets, liver enzymes, and lactate dehydrogenase before and after delivery. The goal was to understand how these biological markers evolve, not to test a treatm…
Sponsor: CHU Mohammed VI Marrakech • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Blood protein clues may predict dangerous pregnancy problems
Knowledge-focused CompletedThis study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Blood DNA levels may signal pregnancy problems
Knowledge-focused CompletedThis study measured the amount of free-floating DNA and nucleosomes in the blood of 137 women to see if these levels differ between those with pregnancy complications (like preeclampsia or blood clots) and healthy women (both pregnant and non-pregnant). The goal was to better und…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Preeclampsia may weaken the heart during pregnancy, new study finds
Knowledge-focused CompletedThis study examined how well the heart relaxes between beats in 80 pregnant women—40 with preeclampsia and 40 healthy. Researchers used ultrasound to measure heart function. The goal was to see if preeclampsia is linked to early signs of heart strain, which could help doctors cat…
Sponsor: University Tunis El Manar • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC