Respiratory paralysis
MONDO:0043775Complete or severe weakness of the muscles of respiration. This condition may be associated with motor neuron diseases; peripheral nerve diseases; neuromuscular junction diseases; spinal cord diseases; injury to the phrenic nerve; and other disorders.
Also known as: paralysis of diaphragm, diaphragmatic paralysis, muscle paralysis, respiratory, muscle paralyzes, respiratory, paralysis, diaphragmatic, paralysis, respiratory, paralysis, respiratory muscle, respiratory muscle paralysis
42 clinical trials for this condition and its sub-types.
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Can targeted breathing exercises help ventilator patients regain diaphragm strength?
Disease control CompletedThis study investigates whether high- or low-intensity inspiratory muscle training (IMT) better improves diaphragm function in patients who have been on mechanical ventilation for over 21 days. Using ultrasound, researchers will measure changes in diaphragm movement and thickness…
Phase: NA • Sponsor: Chang Gung Memorial Hospital • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Simple stretch may speed diaphragm recovery after heart surgery
Disease control CompletedThis study investigates whether adding a contract-relax physical therapy technique to standard respiratory care can improve diaphragm function in patients who develop diaphragmatic paresis after cardiac surgery. The trial enrolls adults who have undergone heart surgery with a hea…
Phase: NA • Sponsor: CMC Ambroise Paré • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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A painless, contact-free vibration sensor may detect hidden heart and lung problems
Diagnosis CompletedThis study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …
Phase: NA • Sponsor: University Hospital, Caen • Aim: Diagnosis
Last updated Jul 31, 2026 00:00 UTC
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Ultrafast ultrasound may offer quicker diagnosis for diaphragm dysfunction
Diagnosis CompletedThis study explores whether ultrafast ultrasound can accurately assess diaphragm function in adults with known or suspected diaphragm dysfunction. Researchers will compare ultrasound measurements with standard tests like pressure measurements and electrical signals from the diaph…
Phase: NA • Sponsor: Institut de Myologie, France • Aim: Diagnosis
Last updated Jul 01, 2026 00:00 UTC
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Less numbing medicine may keep diaphragm working during shoulder surgery
Symptom relief CompletedThis study tested whether using a smaller amount of a weaker numbing medicine (ropivacaine) during a shoulder nerve block could reduce the risk of temporary diaphragm paralysis. 60 adults having shoulder surgery took part. The goal was to see if the low-dose approach could still …
Phase: PHASE3 • Sponsor: University Hospital, Lille • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
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Shoulder surgery pain study: which nerve block works best?
Symptom relief CompletedThis study tested two methods of numbing the suprascapular nerve (a nerve in the shoulder) to control pain after arthroscopic shoulder surgery. Sixty adults scheduled for shoulder surgery received either an anterior or posterior nerve block. Researchers measured pain levels, diap…
Phase: NA • Sponsor: Istanbul Medeniyet University • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Breathing training offers hope for COVID Long-Haulers with weak diaphragms
Symptom relief CompletedThis study looked at whether 6 weeks of special breathing exercises (inspiratory muscle training) can improve diaphragm strength and reduce shortness of breath in 18 COVID-19 survivors who still had trouble breathing. Participants had proven diaphragm weakness and no other explan…
Phase: NA • Sponsor: RWTH Aachen University • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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New nerve block combo may spare breathing while killing shoulder pain
Symptom relief CompletedThis study tested two ways to numb the shoulder after surgery: the standard interscalene block and a combination of two other blocks (infraclavicular and anterior suprascapular). The goal was to see if the combination could provide equal pain relief without causing temporary diap…
Phase: NA • Sponsor: University of Chile • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Can a computer speed up breathing recovery in kids?
Symptom relief CompletedThis study tested whether a computer-driven system called Smartcare/PS could help children with respiratory failure come off a breathing machine faster than usual care. Thirty children were enrolled, and the system automatically adjusted breathing support based on each child's ne…
Phase: NA • Sponsor: St. Justine's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Patients take control: Self-Sedation may ease anxiety in the ICU
Symptom relief CompletedThis study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device. 161 adults in the ICU were randomly assigned to either self-manage their sedation or have it managed by a nurse. The goal was to see if…
Phase: PHASE2, PHASE3 • Sponsor: Mayo Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Baby breathing machine under the microscope: new study watches how it works
Knowledge-focused CompletedThis study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…
Sponsor: Maquet Critical Care AB • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Ultrasound reveals how a neck nerve block may impact the diaphragm
Knowledge-focused CompletedThis study uses ultrasound to measure diaphragm movement and breathing in 15 adults receiving a stellate ganglion block — a nerve injection for certain pain conditions. The goal is to see how often the block temporarily paralyzes one side of the diaphragm. Researchers also check …
Sponsor: Jose Manuel López González • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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Shoulder block study checks for breathing side effects
Knowledge-focused CompletedThis study observed 61 adults having shoulder surgery to see how a specific combination of nerve blocks affects the diaphragm, the main muscle for breathing. Researchers used ultrasound to measure diaphragm movement before and after the block. The goal was to find out if this tec…
Sponsor: Gazi University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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What's it like to live with a home breathing machine? new study asks patients and families
Knowledge-focused CompletedThis study looked at the experiences of 126 people in Denmark who rely on a breathing machine at home, along with their families and the trained caregivers who help them. The goal was to understand the challenges and successes of this life-sustaining care. No new treatments were …
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Heart surgery patients: one in six may face hidden diaphragm trouble
Knowledge-focused CompletedThis study tracked 157 heart surgery patients to see how many still have a weak diaphragm 7 days after their operation. Using ultrasound, researchers measured diaphragm movement during breathing and sniffing. The goal is to understand how common persistent diaphragm problems are …
Sponsor: CMC Ambroise Paré • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Which ventilator mode is best? new study aims to find out
Knowledge-focused CompletedThis pilot study tested three common ventilator modes—volume control, pressure control, and adaptive pressure control—in 566 ICU adults with respiratory failure. The goal was to see which mode leads to more days alive and off the ventilator. The study is a first step to guide fut…
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Oxford researchers seek better way to open collapsed lungs in ICU
Knowledge-focused CompletedThis University of Oxford study looked at 48 ICU patients on ventilators for respiratory failure. Doctors sometimes inflate the lungs briefly (a recruitment manoeuvre) to reopen collapsed areas, but it's unclear when this helps. Researchers used a device to measure lung volume an…
Sponsor: University of Oxford • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Which arm block spares the diaphragm? new study pits two techniques Head-to-Head
Knowledge-focused CompletedThis study compared two ultrasound-guided nerve block techniques for hand, wrist, or forearm surgery to see which one causes less temporary diaphragm paralysis. 91 adults were randomly assigned to receive either a costoclavicular or lateral sagittal infraclavicular block. The goa…
Phase: NA • Sponsor: Gazi University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Brain waves may predict ventilator weaning success
Knowledge-focused CompletedThis study looked at whether measuring tiny brain signals during a breathing test can help predict if a patient on a ventilator will successfully breathe on their own. Researchers monitored 70 intubated adults as they tried breathing without the machine. The goal is to find a sim…
Phase: NA • Sponsor: Poitiers University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Small study tests best ventilator settings for ICU breathing measurements
Knowledge-focused CompletedThis study looked at 24 critically ill patients on breathing machines to see how changing the machine's settings affects measurements of breathing effort. Researchers compared a simple bedside measurement with a more invasive gold-standard technique. The goal was to find the best…
Phase: NA • Sponsor: Fondazione IRCCS San Gerardo dei Tintori • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:16 UTC