Pulmonary edema

This study compares a new type of breathing device (biphasic cuirass ventilator) to standard non-invasive ventilation in 50 high-risk patients who are about to have their breathing tube removed. The goal is to see if the new device can reduce the number of patients who need to be…

This study aims to improve treatment for severe high altitude pulmonary edema (fluid in the lungs) and cerebral edema (brain swelling). Researchers will test breathing support devices and inhaled nitric oxide gas in over 3,000 patients in Tibet. The goal is to speed up recovery, …

This study tests whether paramedics can use a lung ultrasound to improve diagnosis of heart failure in patients with breathing trouble. About 1,000 adults with shortness of breath will receive the ultrasound during emergency care. Researchers will compare the paramedic's diagnosi…

This study looks at whether adding a type of stretching called proprioceptive neuromuscular facilitation (PNF) to standard breathing exercises helps patients get off a breathing machine faster. About 93 adults in the ICU who are stable and awake will be split into three groups: o…

This study tests a redesigned non-invasive ventilation mask that may help people with respiratory insufficiency breathe more easily. Sixty adults who are stable on NIV will wear their usual mask for one hour and then the new mask for one hour. Researchers will measure breathing r…

This study looks at how a small opening in the heart, called a patent foramen ovale (PFO), affects blood flow and oxygen levels during exercise and simulated high altitude. About a third of people have this opening, which may allow oxygen-poor blood to mix with oxygen-rich blood,…

This pilot study investigates how standard changes to mechanical ventilator settings—such as breath size, flow rate, and pressure—affect shortness of breath in awake patients on ventilators. Many ICU patients experience breathlessness despite sedation, which may contribute to PTS…

This study looks at 88 ICU patients who are ready to try breathing on their own after being on a ventilator. Some patients will be taken off the ventilator completely (T-piece test), while others will breathe with a little machine help (PS-ZEEP test). The goal is to see which tes…

This study looks at whether ventilating only one lung during heart-lung bypass surgery can reduce fluid buildup and lung damage in high-risk patients. Forty-five older adults having major elective heart surgery will take part. The goal is to see if this approach leads to better l…

This study tests whether a special ultrasound technique, called VExUS, can predict which ICU patients will have trouble breathing on their own after being on a ventilator. Researchers will scan the veins of 350 patients just before a breathing trial. The goal is to see if signs o…

This study will compare two ways of measuring pressure inside the heart during heart surgery: the gold standard (direct left atrial pressure) and a more common indirect method (pulmonary capillary wedge pressure). Researchers want to see if the indirect method is accurate enough …