Pulmonary edema
MONDO:0006932Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure).
Also known as: edema, pulmonary
85 clinical trials for this condition and its sub-types.
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Broader categories
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One-Size-Fits-All oxygen may be outdated: new trial tests personalized targets
Disease control ENROLLING_BY_INVITATIONThis study is testing whether giving each patient on a ventilator a personalized oxygen target (based on their unique health data) leads to better outcomes than standard care. Researchers will compare death rates and time spent on the ventilator between the two groups. The trial …
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Robot trainer aims to keep seniors on their feet during hospital stays
Disease control OngoingThis study tests whether robot-assisted leg exercises can prevent older patients from losing strength and independence during a hospital stay. 488 patients aged 65 and older will either receive robot-guided training or standard care. The goal is to see if the robot helps them wal…
Phase: NA • Sponsor: Odense University Hospital • Aim: Disease control
Last updated Jun 26, 2026 14:52 UTC
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Could a thyroid hormone boost oxygen in severe lung failure?
Symptom relief OngoingThis study tests whether giving a thyroid hormone (T3) directly into the lungs can safely improve oxygen levels in adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 68 critically ill patients on ventilators will either receive the hormone or s…
Phase: PHASE2 • Sponsor: University of Minnesota • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Ultrasound for all: 9,000-Patient trial tests quicker hospital stays
Knowledge-focused OngoingThis study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…
Sponsor: National Taiwan University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Ultrasound peek at diaphragm could guide breathing support
Knowledge-focused OngoingThis study observes how the diaphragm works in 100 adults with acute respiratory failure who need non-invasive breathing support or high-flow oxygen. Researchers use ultrasound to measure diaphragm movement and thickness at different support levels. The goal is to understand how …
Sponsor: Foro Internacional en Cuidado Crítico • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Baby breathing machine under the microscope: new study watches how it works
Knowledge-focused OngoingThis study watches how a high-frequency ventilator (Servo-n HFOV) works in real hospital use for babies with severe breathing failure. About 75 infants will be observed to see if the machine safely helps them get enough oxygen and remove carbon dioxide. The goal is to gather info…
Sponsor: Maquet Critical Care AB • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Breathing test may predict ventilator weaning failure
Knowledge-focused TerminatedThis study aimed to see if a simple breathing test (Müller maneuver) could predict which patients on ventilators would develop fluid in their lungs during a weaning trial. The test measures changes in heart output to assess fluid status. The study was withdrawn before enrolling a…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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New breath test could replace painful lung scopes
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…
Phase: PHASE2 • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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New study aims to perfect fluid checks for kidney patients
Knowledge-focused OngoingThis study looks at better ways to check fluid levels in adults with acute kidney injury (AKI). AKI is a sudden drop in kidney function that can be made worse by too little or too much fluid. Researchers will compare different assessment methods, including physical exams and bioi…
Sponsor: University of Hertfordshire • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC
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Brain scans reveal hidden links between body diseases and metabolism
Knowledge-focused OngoingThis study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…
Sponsor: The First Affiliated Hospital of Zhengzhou University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC