Primary lymphedema

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested injecting bleomycin directly into cystic hygromas (fluid-filled birthmarks) in 30 children aged 1 month to 12 years. The fluid was drained and bleomycin injected, repeated every 4 weeks until the lump shrank. Most children saw significant size reduction, with so…

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This phase 2 trial tested whether taking iohexol by mouth can treat chylous ascites, a leak of lymphatic fluid that can happen after abdominal or pelvic cancer surgery. The study enrolled 42 patients who developed this condition after surgery. The goal was to see if oral iohexol …

This study tested a cream containing sirolimus on rare skin growths called microcystic lymphatic malformations, which can ooze, bleed, and cause pain. 55 children and adults applied the cream to one area and a placebo cream to another for 12 weeks. The goal was to see if the siro…

This phase 2 trial tested the drug sirolimus (rapamycin) in 61 children and young adults with complicated vascular anomalies—abnormal blood vessel growths that can cause pain, bleeding, or organ problems. The goal was to see if sirolimus could safely shrink these anomalies and im…

This early-stage trial tested an oral drug called JAB-3312 in 40 adults with advanced solid tumors (like lung, colon, or breast cancer) that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects. Researchers also looked …

This study tested the DePuy LCS Complete mobile-bearing total knee system in 241 people needing knee replacement due to arthritis. The goal was to see how well the implant and surgical tools work during and after surgery. Researchers measured implant survival, knee function, and …

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after th…

This study looked at whether adding manual lymph drainage to standard compression therapy improves outcomes for people with lower leg lymphedema. Thirty-one participants were randomly assigned to receive either compression alone or compression plus manual lymph drainage. The rese…

This study tested a wearable compression device called Dayspring for people with lymphedema in one leg. 24 adults used the device daily for 3 months. Researchers measured changes in leg swelling and quality of life to see if the device was safe and helpful.

This study looked at how four different drinks—two prebiotic sodas, regular Coca-Cola, and Diet Coke—affect hunger, blood sugar, insulin, and appetite hormones in healthy men aged 18-40. Ten participants visited the lab four times, each time drinking one of the beverages in a ran…

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study looked at how children with Noonan syndrome process energy and sugar. Researchers measured insulin sensitivity in 20 children with the condition to see if they have unique metabolic traits. The goal was to better understand the disease, not to test a new treatment.

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This study tested different doses of oliceridine, a painkiller, to find the amount that best prevents sudden rises in blood pressure and heart rate when a breathing tube is placed during anesthesia. Researchers enrolled 58 adults having elective surgery and adjusted doses based o…

This study looked at a questionnaire designed to measure how leg swelling (lymphedema) affects daily life. Researchers tested a French version for accuracy and checked if the Dutch version can track changes over time. Over 450 people with leg lymphedema filled out the questionnai…