Postgastrectomy syndrome

This trial compares two weight-loss surgeries in people with severe obesity (BMI 50-60). One is the standard Roux-en-Y gastric bypass, the other a newer sleeve gastrectomy with duodenojejunal bypass. The goal is to see which procedure leads to healthier hormone responses after me…

This expanded access program offers avexitide to people with post-bariatric hypoglycemia (dangerously low blood sugar) after Roux-en-Y gastric bypass. Eligible patients include those who completed the LUCIDITY trial or other avexitide studies. Participants receive a daily injecti…

This study tests whether a continuous glucose monitor (CGM) can better detect low blood sugar episodes in people who had gastric bypass surgery and now have late dumping syndrome. Sixty participants will either use the iCan i3 CGM or standard fingerstick tests for 60 days. The go…

This study tests if a tube-like device called a stent, placed through a scope, can reverse gastric bypass surgery in 20 people who have serious complications like low blood sugar, blockages, or liver problems. The goal is to see if the stent works as well as surgery to fix these …

This trial is developing an AI-powered device that listens to children's heart, breath, and bowel sounds to identify signs of common diseases like congenital heart disease, bronchopneumonia, and abdominal issues. It will involve 30,000 children aged 0-18, some with these conditio…

This study looks at whether a small, wearable continuous glucose monitor (CGM) can accurately diagnose dumping syndrome in people who have had surgery for esophageal cancer. Dumping syndrome happens when food moves too quickly into the small intestine, causing symptoms like dizzi…

This observational study looks at how bariatric surgery changes cortisol metabolism and whether that contributes to reactive hypoglycemia (low blood sugar after meals). Researchers will measure cortisol levels during a meal test and check adrenal function in 100 people who had ga…

This study looks at why some babies born with esophageal atresia develop dumping syndrome, a condition causing dangerous blood sugar drops after feeding. Researchers will monitor 15 infants with continuous glucose and heart monitors and a stomach-emptying scan at 3 months old. Th…

This small pilot study aims to see if a new in-ear wearable device can comfortably and reliably measure blood flow changes in the head. Researchers will compare people who have low blood sugar after bariatric surgery to those who don't. The goal is to learn if this device can hel…

This study looks at how gastric bypass and sleeve gastrectomy affect blood sugar control after eating. Researchers will give two drugs—Exendin-(9-39) and atropine—to understand the roles of hormones and nerves. The goal is to learn why some patients develop low blood sugar after …

This study looks at how a hormone called GLP-1 helps control blood sugar and weight loss after gastric bypass surgery. Researchers will give a drug that blocks GLP-1 to 80 people, including those who had surgery and healthy controls, to measure its effects. The goal is to underst…