Portal vein thrombosis
MONDO:0001339The formation of a blood clot (thrombus) in the portal vein.
Also known as: portal vein thrombotic disease, thrombotic disease of portal vein
23 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New combo therapy shows promise for tough-to-treat liver cancer
Disease control CompletedThis study tested a combination of proton beam radiotherapy followed by two drugs (Tecentriq and Avastin) in 63 adults with advanced liver cancer that had spread into the portal vein. The goal was to see if this approach could help control the cancer and improve survival. Partici…
Phase: PHASE2 • Sponsor: Samsung Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New blood test could save lives in liver failure bleeding emergencies
Disease control CompletedThis study tested whether a special blood test (ROTEM) can better guide blood transfusions in people with acute-on-chronic liver failure who are bleeding from enlarged veins. 262 participants were randomly assigned to receive transfusions based on either the new test or standard …
Phase: NA • Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New combo therapy shows promise for tough liver cancer
Disease control CompletedThis study tested a three-drug combination for people with advanced liver cancer that has spread into the portal vein (a major blood vessel). The treatment adds a liver-directed chemotherapy infusion to two standard drugs (lenvatinib and a PD-1 inhibitor). The goal was to see if …
Phase: PHASE2 • Sponsor: Peking University • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Liver transplant breakthrough: new Clot-Busting technique saves grafts
Disease control CompletedThis study tested a new way to treat severe blood clots in the portal vein during liver transplant surgery. Doctors used a special approach through a ligament in the donor liver to place stents or close off abnormal veins. The study included 75 patients and found the method safe …
Sponsor: Chiyi Chen • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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AI matches doctors in spotting early vein disease
Diagnosis CompletedThis study tested whether an AI app (IVENUS) could correctly classify the severity of chronic vein disease from leg photos. Over 1,600 patients had their legs photographed, and the app's diagnosis was compared to that of experienced doctors. The goal was to see if the app could r…
Phase: NA • Sponsor: Clinic of Phlebology and Laser Surgery, Chelyabinsk, Russia • Aim: Diagnosis
Last updated Jun 27, 2026 09:10 UTC
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Stent procedure eases severe symptoms in cancer patients with blocked veins
Symptom relief CompletedThis study looked at placing a small metal tube (stent) into the portal vein of 63 cancer patients whose vein was blocked by a tumor. The goal was to relieve serious symptoms like fluid buildup in the belly or bleeding in the gut. The procedure was done through a needle in the li…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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Computer model helps cirrhosis patients get blood thinner doses right faster
Knowledge-focused CompletedThis study tested whether a computer program (Simcyp) could help doctors choose the right starting dose of warfarin, a blood thinner, for 21 patients with liver cirrhosis and a blood clot in the portal vein. The goal was to see if the program helped patients reach a safe, effecti…
Phase: PHASE4 • Sponsor: Kafrelsheikh University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Birth control pills under scrutiny for vein disease link
Knowledge-focused CompletedThis study looked at whether combined oral contraceptives (birth control pills) influence the development or worsening of chronic venous diseases, like varicose veins. Researchers followed 116 women taking different types of birth control pills. The goal was to see if these pills…
Phase: NA • Sponsor: Clinic of Phlebology and Laser Surgery, Chelyabinsk, Russia • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Teens with blood disorders share their stories in new study
Knowledge-focused CompletedThis study interviewed 15 children aged 12 to 21 who have bleeding or clotting disorders. Researchers asked about their quality of life, confidence in managing their condition, and how they view the care they receive. The goal is to better understand the real-life challenges thes…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC