Peritonitis

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study compared two antibiotics—ciprofloxacin and ceftriaxone—given intravenously to 310 patients with liver cirrhosis who developed a serious infection called spontaneous bacterial peritonitis. The goal was to see which drug better controlled fever, abdominal pain, and infec…

This study compared two surgical methods for treating a burst section of the colon caused by diverticulitis, a condition that leads to severe abdominal infection. 102 adults with this infection were randomly assigned to either a traditional two-step surgery (Hartmann procedure) o…

This study looked at 78 patients who had emergency abdominal surgery for serious infections. Doctors compared closing the wound right away versus leaving it open for a few days to drain before closing. The goal was to see which method leads to fewer infections and wound problems.

This study tested two new antibiotic combinations (cefepime/nacubactam and aztreonam/nacubactam) against the best available treatments for adults with serious infections like urinary tract infections, pneumonia, and abdominal infections caused by carbapenem-resistant bacteria. Th…

This study tested whether a new training package called TEACH-PD could lower infection rates in patients starting peritoneal dialysis (PD). Over 1,400 adults from multiple countries were randomly assigned to receive either the TEACH-PD training or standard PD training. The resear…

This study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…

This study looked at 50 adults who had emergency surgery for a belly infection (peritonitis). It compared a special vacuum dressing (NPWT) with standard wound closure to see which better prevents surgical site infections. The goal was to find a way to help wounds heal faster and …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a simple strip test called PeriScreen to quickly diagnose infection in the belly fluid of people with cirrhosis. The goal is to see if the strip can spot infections as accurately as standard lab tests, helping doctors start treatment faster. About 649 adults wit…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study tested whether measuring a substance called BD glucan in the abdominal fluid of ICU patients with peritonitis can diagnose fungal infections faster than standard lab cultures. Fungal peritonitis is deadly, and current tests take at least 48 hours. The study enrolled 12…

This study looked at whether doxycycline, a common antibiotic, can prevent spontaneous bacterial peritonitis (SBP) in people with cirrhosis. SBP is a serious infection of the belly fluid that can be life-threatening. The study included 841 adults with cirrhosis who were at risk f…

This study tested whether regular retraining on infection prevention can lower peritonitis rates in new peritoneal dialysis patients. Over 700 adults from eight European countries were randomly assigned to either standard care or extra testing and retraining on dialysis technique…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at whether a rapid test called multiplex PCR can identify the germs causing serious abdominal infections faster than the usual lab culture method. Researchers collected fluid samples from 50 patients during surgery and compared the time each method took to find …

This study looked at the records of 2500 adults admitted to the hospital with serious belly problems like blockages or infections. The goal was to compare outcomes for different treatments, including surgery, keyhole surgery, radiology procedures, and comfort care. By grouping pa…

This completed Phase 4 study looked at how the body processes echinocandin antifungal drugs (caspofungin or micafungin) in 24 adults with septic shock caused by peritonitis. Researchers measured drug levels in the blood to understand clearance, distribution, and concentration. Th…

This study observed 200 adults who came to the emergency room with a suspected abdominal infection that needed surgery. Researchers wanted to see how quickly patients received antibiotics and surgery, and how that affected their hospital stay. The goal was to find factors that le…

This study looked at whether a substance called β-D-glucan in the blood can help identify and track fungal infections in the abdomen (peritonitis) in intensive care patients. Researchers measured levels in 70 adults with peritonitis, comparing those with and without Candida yeast…