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Parkinsonian disorder
MONDO:0021095A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
1311 clinical trials for this condition and its sub-types, 67 tagged with Parkinsonian disorder itself.
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Sub-types of Parkinsonian disorder
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Parkinson disease 1,165 trials · 1,292 incl. sub-types
6 sub-types
- Late-onset Parkinson disease 3 trials · 143 incl. sub-types Sub-types →
- Young-onset Parkinson disease 9 trials · 11 incl. sub-types Sub-types →
- Parkinson disease 16 0 trials
- Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development 0 trials
- Parkinson disease, mitochondrial 0 trials
- Parkinsonian-pyramidal syndrome 0 trials Sub-types →
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Vascular parkinsonism 4 trials
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Dystonia 12 2 trials
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Perry syndrome 0 trials
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X-linked dystonia-parkinsonism 0 trials
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Atypical juvenile parkinsonism 0 trials
1 sub-type
- Juvenile onset Parkinson disease 19A 0 trials
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Cyanide-induced parkinsonism 0 trials
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Dystonia 16 0 trials
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Encephalitis lethargica 0 trials
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Parkinsonism with polyneuropathy 0 trials
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Parkinsonism-dystonia, infantile 0 trials
3 sub-types
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Postencephalitic Parkinson disease 0 trials
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Primary progressive freezing gait 0 trials
Most studied deeper sub-types
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New pill aims to slow Parkinson's progression in early stages
Disease control Recruiting nowThis study tests whether a daily pill called BHV-8000 can slow the worsening of motor skills in people recently diagnosed with Parkinson's disease. About 550 adults aged 40 to 85 with early Parkinson's will receive either BHV-8000 (10 mg or 20 mg) or a placebo for up to 48 weeks.…
Phase 2/3 • Sponsor: Biohaven Therapeutics Ltd. • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Can a Two-Drug combo quiet the tremors Parkinson's patients still feel?
Disease control Recruiting nowThis phase 2 trial tests an experimental drug called VIM0423 in adults with Parkinson's disease whose tremor does not respond well to standard dopaminergic therapy. Researchers want to see if VIM0423 can reduce tremor severity, improve daily function and quality of life, and be s…
Phase 2 • Sponsor: Vima Therapeutics • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New brain scan could spot Parkinson's earlier
Diagnosis Recruiting nowThis study tests whether a special imaging agent called 18F-FPyCO/SMBT-1 can help diagnose Parkinson's disease and related conditions by detecting a brain enzyme called MAO-B. About 200 adults with suspected or confirmed Parkinson's will receive a single injection of the agent an…
Sponsor: Tianjin Medical University • Aim: Diagnosis
Last updated Sep 10, 2026 00:00 UTC
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Colonoscopy could spot Parkinson's before symptoms worsen
Diagnosis Recruiting nowThis study tests whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers look for a protein called alpha-synuclein in the colon of people already diagnosed with Parkinson's. If successful, this could lead to earlier detection a…
Sponsor: CND Life Sciences • Aim: Diagnosis
Last updated Jun 27, 2026 09:05 UTC
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Can a phone app nudge people toward exercise and slow Parkinson's?
Prevention Recruiting nowThis trial tests whether a smartphone app can help people with REM sleep behavior disorder, a condition that often precedes Parkinson's, become more physically active over two years. Participants receive personalized activity goals through the app and track their steps and exerci…
Sponsor: Radboud University Medical Center • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Could a phone app nudge people to exercise and slow Parkinson's before symptoms appear?
Prevention Recruiting nowThis trial tests whether a smartphone app can help 600 people with Parkinson's-related gene mutations increase their daily physical activity over two years. Participants set their own exercise goals and get feedback through the app. Researchers will measure changes in step counts…
Sponsor: Radboud University Medical Center • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Step toward prevention: app-based exercise may protect the brain in Parkinson's risk group
Prevention Recruiting nowThis study tests whether increasing physical activity through a motivational smartphone app can slow cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease and related disorders. Researchers will enroll 130 participants …
Sponsor: University Hospital, Bonn • Aim: Prevention
Last updated Jun 27, 2026 08:11 UTC
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Could a few minutes of special breathing help Parkinson's patients speak louder and move better?
Symptom relief Recruiting nowThis pilot study tests whether a single session of breathing air with slightly higher carbon dioxide and lower oxygen can improve speech, cough, and movement in people with Parkinson's disease. Participants are randomly assigned to one of two breathing patterns, each lasting abou…
Sponsor: University of Florida • Aim: Symptom relief
Last updated Aug 23, 2026 00:00 UTC
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Can tailored magnetic pulses ease Parkinson's symptoms?
Symptom relief Recruiting nowThis study tests whether a personalized form of transcranial magnetic stimulation (TMS) can improve motor and non-motor symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty participants will receive 10 days of targeted TMS…
Sponsor: Peking University First Hospital • Aim: Symptom relief
Last updated Jul 01, 2026 00:00 UTC
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Magic mushroom therapy tested for depression in chronic illness patients
Symptom relief Recruiting nowThis study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…
Phase 2 • Sponsor: University Medical Center Groningen • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Tailored brain zaps could help Parkinson's patients walk better
Symptom relief Recruiting nowThis study tests a personalized approach to brain stimulation (rTMS) for people with Parkinson's disease. The goal is to see if tailoring the stimulation to each patient's brain function improves walking better than the standard one-size-fits-all method. The study will involve 60…
Sponsor: Samsung Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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Blood flow trick may boost balance in Parkinson's patients
Symptom relief Recruiting nowThis study tests a new exercise method for people with Parkinson's disease. Researchers will see if partially restricting blood flow to the legs during balance-challenging strength exercises can improve symptoms. The study involves 20 participants aged 40 to 85 and focuses on whe…
Sponsor: The University of Texas Health Science Center at San Antonio • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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Rotational exercises may cut fall risk in Parkinson's patients
Symptom relief Recruiting nowThis study tests whether functional rotational exercises can lower fall risk and improve mobility and balance in people with Parkinson's disease. Researchers will enroll 50 adults aged 50-70 with mild to moderate Parkinson's. Participants will perform rotational exercises, and th…
Sponsor: Uskudar University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Could a gentle brain zap help Parkinson's patients swallow safely?
Symptom relief Recruiting nowThis study tests whether a mild electrical brain stimulation technique called tDCS can improve swallowing difficulties in people with Parkinson's disease. 58 participants will receive either real or sham tDCS alongside standard swallowing therapy. Researchers will measure changes…
Sponsor: Wang Ping • Aim: Symptom relief
Last updated Jun 26, 2026 13:36 UTC
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Can we decode the hidden subtypes of early Parkinson's?
Knowledge-focused Recruiting nowThis study investigates the biological mechanisms behind young-onset Parkinson's disease, which begins before age 50. Researchers will analyze genetic tests and protein markers in spinal fluid and skin biopsies from 250 participants to identify distinct disease subtypes. The goal…
Sponsor: NYU Langone Health • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Can a Thigh-Worn sensor outsmart dizziness questionnaires?
Knowledge-focused Recruiting nowThis study explores whether a small accelerometer worn on the thigh can objectively measure how well treatments work for neurogenic orthostatic hypotension—a condition causing dizziness and fainting upon standing. Participants wear the device for one week on placebo and one week …
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Parkinson's sleep study: does turning brain stimulation off at night help?
Knowledge-focused Recruiting nowThis study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Twenty participants who already have a DBS implant will spend two nights in a sleep lab—one night with the device on and one night with it off. Researchers will measure sleep qu…
Sponsor: The University of Texas Health Science Center at San Antonio • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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New DBS settings aim to improve walking in Parkinson's patients
Knowledge-focused Recruiting nowThis study compares two different deep brain stimulation (DBS) settings in 30 people with Parkinson's disease who already have DBS implants. The goal is to see which setting better improves walking and balance problems. Participants will try both settings, and their symptoms will…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Scientists launch 5-Year study to unravel Parkinson's mysteries
Knowledge-focused Recruiting nowThis study follows 640 participants—including people with Parkinsonism, those with REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers will use brain scans, movement tests, voice analysis, and other tools to track how the disease progresses and improve di…
Sponsor: Ruijin Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Parkinson's puzzle: does it start in the brain or the body?
Knowledge-focused Recruiting nowThis study follows 150 people with early-stage Parkinson's disease to see if the condition starts in the brain or the body first. Researchers will track symptoms like walking problems and thinking changes over 5 years using tests, scans, and questionnaires. The goal is to better …
Sponsor: Azienda USL Reggio Emilia - IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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700-Patient study aims to unravel the mystery of freezing gait
Knowledge-focused Recruiting nowThis study is gathering information from 700 people with Parkinson's disease or similar conditions who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will track symptoms, walking patterns, and falls over three years using questionnair…
Sponsor: Tianjin Huanhu Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Brain pacemaker study aims to unlock sleep secrets in Parkinson's
Knowledge-focused Recruiting nowThis study looks at how deep brain stimulation (DBS) — a device already used to control movement in Parkinson's disease — affects sleep. Researchers will monitor brain activity and sleep quality in 64 adults with Parkinson's who have or will get DBS implants. The goal is to under…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Can homeopathy and herbalism help Parkinson's? new study aims to find out
Knowledge-focused Recruiting nowThis study is observing 100 people with Parkinson's disease who are receiving complementary therapies like homeopathy, herbalism, hypnosis, and healing at a special clinic. Participants also get advice on lifestyle, mindfulness, and diet. The goal is to document their experiences…
Sponsor: St. Mary's University, Twickenham • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Massive Parkinson's registry launches in china to track 100,000 patients
Knowledge-focused Recruiting nowThis study aims to collect health information from 100,000 people with Parkinsonian disorders in China over 10 years. Participants use an online platform to report symptoms, quality of life, and other health details every 3 months. The goal is to better understand how the disease…
Sponsor: Huashan Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC