Osteogenesis imperfecta
MONDO:0019019Osteogenesis imperfecta (OI) comprises a heterogeneous group of genetic disorders characterized by increased bone fragility, low bone mass, and susceptibility to bone fractures with variable severity.
Also known as: Lobstein disease, OI, Osteopsathyrosis, Porak and Durante disease, brittle bone disease, glass bone disease, Vrolik disease
329 clinical trials for this condition and its sub-types, 35 tagged with Osteogenesis imperfecta itself.
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Sub-types of Osteogenesis imperfecta
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Osteogenesis imperfecta and a reduction of bone mineral density. 0 trials · 307 incl. sub-types
34 sub-types
- Osteoporosis 277 trials · 295 incl. sub-types Sub-types →
- Osteogenesis imperfecta type 3 9 trials
- Osteogenesis imperfecta type 1 8 trials Sub-types →
- Osteogenesis imperfecta type 4 7 trials
- Osteogenesis imperfecta type 5 1 trial
- Bruck syndrome 2 0 trials
- Cole-Carpenter syndrome 1 0 trials
- Cole-Carpenter syndrome 2 0 trials
- Ehlers-Danlos syndrome, spondylodysplastic type, 1 0 trials
- Singleton-Merten syndrome 1 0 trials
- Singleton-Merten syndrome 2 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- Autosomal recessive cutis laxa type 2A 0 trials Sub-types →
- Autosomal recessive cutis laxa type 2B 0 trials
- Calvarial doughnut lesions-bone fragility syndrome 0 trials
- Geroderma osteodysplastica 0 trials
- Gnathodiaphyseal dysplasia 0 trials
- Osteogenesis imperfecta type 10 0 trials
- Osteogenesis imperfecta type 11 0 trials
- Osteogenesis imperfecta type 12 0 trials
- Osteogenesis imperfecta type 14 0 trials
- Osteogenesis imperfecta type 15 0 trials
- Osteogenesis imperfecta type 16 0 trials
- Osteogenesis imperfecta type 17 0 trials
- Osteogenesis imperfecta type 2 0 trials
- Osteogenesis imperfecta type 6 0 trials
- Osteogenesis imperfecta type 7 0 trials
- Osteogenesis imperfecta type 8 0 trials
- Osteogenesis imperfecta type 9 0 trials
- Osteogenesis imperfecta, type 18 0 trials
- Osteogenesis imperfecta, type 19 0 trials
- Osteoporosis-pseudoglioma syndrome 0 trials
- Short stature-optic atrophy-Pelger-Huët anomaly syndrome 0 trials
- Spondylo-ocular syndrome 0 trials
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Brittle bone disorder 4 trials
1 sub-type
- Brittle bone syndrome lethal type 0 trials
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Osteogenesis imperfecta type 13 0 trials
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Osteogenesis imperfecta, IIA 22 0 trials
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Osteogenesis imperfecta, type 20 0 trials
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Osteogenesis imperfecta, type 21 0 trials
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Osteogenesis imperfecta, type 23 0 trials
Most studied deeper sub-types
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New shot aims to fortify fragile bones in brittle bone disease trial
Disease control Recruiting nowThis study tests a drug called AGA2115 in 80 adults with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug increases bone density in the spine after 1…
Phase 2 • Sponsor: Angitia Incorporated Limited • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New shot aims to toughen fragile bones in rare disease
Disease control Recruiting nowThis phase 2 trial tests a drug called AGA2115 in 48 Chinese adults and adolescents with osteogenesis imperfecta (types I, III, IV), a condition that makes bones brittle. Participants receive one of three dose schedules by injection under the skin. The study checks for side effec…
Phase 2 • Sponsor: Angitia Biopharmaceuticals Guangzhou Limited • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Brittle bone kids: is romosozumab safe Long-Term?
Disease control Recruiting nowThis study follows children and teens with osteogenesis imperfecta (brittle bone disease) who previously received romosozumab in an earlier trial. Researchers will monitor 71 participants for side effects over time. The goal is to see if the drug is safe for long-term use in this…
Phase 3 • Sponsor: Amgen • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Brittle bone breakthrough? drug may restore hearing
Disease control Recruiting nowThis study tests whether bisphosphonates, drugs commonly used to strengthen bones, can also treat hearing loss in people with Osteogenesis Imperfecta (OI) type I. Researchers will enroll 100 adults and children with OI, giving some the drug and comparing their hearing over time. …
Phase 4 • Sponsor: Hospital for Special Surgery, New York • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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BONeMOVE: exercise boosts stamina in kids with brittle bones
Symptom relief Recruiting nowThis study tests whether a 6-month adapted physical activity program can improve endurance and quality of life in 30 children and teenagers with osteogenesis imperfecta (brittle bone disease). Participants will do supervised exercises designed for their condition. The main goal i…
Sponsor: University Hospital, Toulouse • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Gentle exercise with cuffs may strengthen bones and muscles in brittle bone disease
Symptom relief Recruiting nowThis study tests a safe, low-intensity exercise program using inflatable cuffs on the legs to improve muscle, bone, and quality of life in 40 adults with osteogenesis imperfecta type I (a mild form of brittle bone disease). Participants will do simple home exercises 2-3 times a w…
Sponsor: University Hospital, Ghent • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC
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Can genetics predict the course of brittle bone disease?
Knowledge-focused Recruiting nowThis study follows up to 1,000 people with osteogenesis imperfecta, also known as brittle bone disease, a rare condition that causes bones to break easily. Researchers aim to connect each person's genetic cause with their symptoms, disease progression, and response to current tre…
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Massive database aims to unlock secrets of facial birth defects
Knowledge-focused Recruiting nowThis study is creating a large database of genetic and physical information from 3100 children with craniofacial abnormalities, such as craniosynostosis and Pierre Robin sequence. Researchers will analyze this data to understand why these conditions vary so much from person to pe…
Sponsor: Imagine Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Radiation-Free bone scan tested in kids
Knowledge-focused Recruiting nowThis study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, such as brittle bone disease or osteoporosis. The goal is to see if REMS can work as well as the standard X-ray method …
Sponsor: Meyer Children's Hospital IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Brittle bones, fragile hearts? new study investigates cardiac risks in OI
Knowledge-focused Recruiting nowThis study is observing 40 people with osteogenesis imperfecta (brittle bone disease) to see how often heart problems occur. Researchers will use standard heart tests like echocardiograms to check for issues. The goal is to create better screening guidelines to catch heart proble…
Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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Brittle bone disease registry opens to track 5,000 patients
Knowledge-focused Recruiting nowThis study is a registry that gathers medical, genetic, and quality-of-life information from people with osteogenesis imperfecta (brittle bone disease). It aims to track how the disease progresses over time and how different genetic changes affect symptoms. No new treatments are …
Sponsor: Luca Sangiorgi • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Brittle bone disease may also affect balance, new study investigates
Knowledge-focused Recruiting nowThis study looks at whether children and young adults (ages 12-20) with osteogenesis imperfecta, also known as brittle bone disease, have problems with their hearing and balance. Participants will undergo hearing tests and special balance assessments, and some may get CT or MRI s…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:39 UTC