Obesity due to SIM1 deficiency

This pilot study tests whether a daily probiotic supplement containing L. acidophilus (strain TW01), originally isolated from fermented coffee grounds, can improve gut health, body composition, and markers of inflammation. Overweight or obese adults aged 18-60 will take either th…

This study looks at whether eating only during a set window each day combined with short, intense exercise can help overweight adults lose fat and improve health markers like blood sugar and cholesterol. One hundred participants will follow this routine remotely for 12 months, wi…

This study tests three home-based programs—healthy eating, physical activity, and gardening—designed to prevent obesity in Hispanic children aged 3 to 4 living in rural West Texas. Over 24 months, researchers will measure changes in body mass index, waist-to-height ratio, and bod…

This study tests whether adding an AI chatbot to a 12-week smartphone weight loss program helps young adults with overweight or obesity lose more weight and stay engaged. Twenty participants will either get the standard program or the program plus a chatbot for extra support. Res…

This study looks at whether sewing shut a specific incision site (the epigastric trocar) during sleeve gastrectomy can prevent hernias from forming later. People having their first sleeve gastrectomy for obesity are included, while those with prior stomach banding or repeat sleev…

This study looks at whether intermittent fasting (eating only two small meals one day per week) can help overweight veterans maintain weight loss after a 12-week diet and exercise program. Researchers will compare this approach to a standard heart-healthy maintenance plan in 175 …

This study tests whether a smartphone app that sets daily step goals can help middle-aged adults (30-70 years old) who are overweight walk more. Participants use a Fitbit and receive adaptive goals to increase light physical activity. The goal is to see if this simple approach ca…

This study tests community-based programs in six countries to help children ages 6-13 eat healthier and be more active. The goal is to prevent obesity and improve quality of life in disadvantaged urban communities. Researchers will track changes in body mass index and health-rela…

This study tested a 24-week weight loss program delivered via video calls for 22 breast cancer survivors who were overweight or obese. The goal was to see if the program was practical and well-liked, and whether it improved quality of life, physical activity, and mood. Participan…

This pilot study tests whether an 8-week program combining mindful eating and yoga is practical and well-liked by adults with overweight or obesity. Researchers will check if participants stick with the program and if it leads to better mindfulness, healthier eating, more physica…

This study looks at whether eating only during an early or late 8-hour window helps overweight adults lose weight and improve health. Researchers will track changes in weight and blood sugar over time. The goal is to find out which eating schedule works best and is easier to stic…

This study looks at whether exercising in the morning or evening makes a difference in weight loss for people who are overweight. Researchers will track weight, body fat, sleep, and eating habits in 128 adults over 13 months. The goal is to find out if timing your workouts can he…

This study looks at whether reducing exposure to everyday chemicals called endocrine disruptors (found in plastics, cosmetics, and food) can help people with overweight or obesity lose weight. About 226 participants will either follow a program to lower chemical exposure or use a…

This study planned to analyze data from a large U.S. health survey to see if eating a diet rich in antioxidants is linked to better metabolic health in overweight or obese adults. Researchers would have looked at body mass index and markers like blood sugar and cholesterol. Howev…

This study looks at whether the standard doses of the antibiotic cefazolin given before bariatric surgery are high enough for obese patients. Researchers will measure drug levels in the blood and tissues of 70 patients to see if they reach the needed concentration to prevent infe…

This study looks at the genes of 1000 people with severe early-onset obesity to find rare genetic causes. It focuses on conditions like Bardet-Biedl syndrome. The goal is to better understand these conditions and improve how they are diagnosed. Participants provide a blood or sal…