Obesity due to SIM1 deficiency

This study tested a 100-day weight management program in 140 overweight adults. The program included meal replacements, protein and fiber supplements, probiotics, diet plans, exercise, and counseling. Researchers measured weight loss and health changes to see if the program is sa…

This early study tested a new medicine, NNC0519-0130, in 161 people to see if it is safe and how it works in the body. The medicine aims to lower blood sugar and reduce appetite, which could help people with type 2 diabetes and overweight. Participants received either the medicin…

This study tested whether giving tranexamic acid (TXA) during weight-loss surgery reduces bleeding. 132 adults having sleeve gastrectomy received either TXA or a placebo right after anesthesia. The results showed that TXA lowered blood loss during and after surgery, without incre…

This study looks at whether giving a nerve block (TAP block) early during laparoscopic sleeve gastrectomy reduces pain more than giving it later. About 200 adults having this weight-loss surgery will receive the same numbing medicine, but at different times. Researchers will comp…

This study compares two types of stitches used during robotic gastric bypass surgery for weight loss. About 150 adults with severe obesity will be randomly assigned to receive either a special barbed suture or a standard one. The main goal is to see which stitch is faster to use …

This study tested whether a short educational video watched before bariatric surgery could lower patients' fear and improve their recovery. Fifty-one adults having weight-loss surgery were randomly assigned to either watch the video or receive standard care. Researchers measured …

This study tested whether adults who have bariatric sleeve gastrectomy (a type of weight-loss surgery) can safely recover at home instead of in the hospital. Twenty-eight participants received acute care at home, including nurse and doctor visits, lab tests, and 24/7 urgent suppo…

This study tested whether using virtual reality glasses for discharge education helps patients better care for themselves after bariatric surgery. Sixty adults who had laparoscopic weight-loss surgery were split into two groups: one received standard care, the other watched a 15-…

This completed trial tested whether a nerve block called erector spinae plane block (ESPB) can reduce pain and opioid use in super obese patients (BMI over 50) after laparoscopic bariatric surgery. Sixty participants received either the ESPB or standard local anesthetic at the in…

This study looked at how the body's metabolism changes when people overeat or fast, and how different diets (like high-protein or high-fat) affect those changes. About 200 healthy adults aged 18-55 participated. The goal was to understand why some people are more resistant to gai…

This study looked back at the records of over 9,000 people who had weight-loss (bariatric) surgery. The goal was to find factors that might predict bleeding during or within 30 days after surgery. By identifying these risk factors, doctors hope to create a score that can help pre…

This completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…

This study looked at how stress influences eating and physical activity in African-American, Hispanic, and white teen girls aged 13-17. Researchers measured food intake after stress and non-stress sessions, along with BMI and activity levels. The goal was to understand why obesit…

This study tested a special stitch device (STRATAFIX Spiral PDS Plus) used in robot-assisted surgeries for weight loss (sleeve gastrectomy) and hysterectomy. 161 adults took part. The main goal was to see how well it controlled bleeding after stitching. Doctors also rated how eas…

This study looked at how safe and effective the easyEndo™ powered stapler is when used in weight-loss surgery. Researchers checked if the stapler worked correctly during and after surgery in 60 patients. The goal was to see if the device is reliable for cutting and sealing tissue…

This study looked at how a new drug called GZR18 is processed in the bodies of 6 overweight or obese men. The drug was given as a single injection, and researchers measured how much of it came out in urine and stool over 78 days. The goal was to understand how the drug is broken …

This completed study observed 563 patients who had weight-loss (bariatric) surgery and received extra oxygen during their first night in the hospital. Researchers tracked how often oxygen levels fell below 90% and what actions nurses took, like adjusting the oxygen flow or reposi…

This study followed 1100 adults with severe obesity who took WEGOVY (semaglutide) for 12 months. Researchers collected data on weight, eating habits, and blood markers to see how the drug worked in different groups. The goal is to use this information, along with artificial intel…