Myasthenia gravis

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…

This study tested an experimental drug called RC18 in 29 adults with systemic myasthenia gravis, a condition that causes muscle weakness. The goal was to see if RC18 is safe and can help control symptoms. Participants received the drug while continuing their usual treatments, and…

This study tested two different ways of giving the drug efgartigimod to people with generalized myasthenia gravis, a condition that causes muscle weakness. One group received the drug continuously, while the other got it in cycles. The goal was to see which schedule works better …

This study looked at the long-term safety of a drug called HBM9161 for people with generalized myasthenia gravis, a condition that causes muscle weakness. It involved 111 patients who had already completed a previous phase 3 study. The goal was to see if the drug is safe to use o…

This early-phase trial tested a new drug called VIS171 in 61 people: first in healthy volunteers, then in patients with autoimmune diseases. The main goal was to check safety and how the body processes the drug. No results on whether it actually helps the disease are available ye…

This study compares two treatments—intravenous immunoglobulin (IVIG) and plasma exchange (PLEX)—for people experiencing a myasthenic crisis, a severe episode of muscle weakness in myasthenia gravis. Fifty adults were treated with either IVIG or PLEX, and their improvement was mea…

This study tested whether people with generalized myasthenia gravis (gMG) can safely and effectively use an auto-injector to give themselves the drug zilucoplan at home. Thirty-one adults who were already on a stable dose of zilucoplan took part. The main goal was to see if they …

This study looked at whether a modified traditional Chinese herbal formula, Guilu Erxian Glue, can help people with myasthenia gravis (a disease causing muscle weakness). Researchers reviewed medical records of 231 patients who took the herbal formula alongside standard Western m…

This study tested the long-term safety of efgartigimod injections in 184 people with generalized myasthenia gravis, a chronic disease that causes muscle weakness. Participants received repeated treatment cycles over time. The goal was to see if the drug is safe and tolerable when…

This completed Phase 3 study tested eculizumab in 15 Chinese patients with refractory generalized myasthenia gravis (gMG), a condition where standard treatments fail. Eculizumab is given by IV infusion and aims to improve daily living activities and muscle strength. The study mea…

This study tested a drug called rozanolixizumab in 200 adults with generalized myasthenia gravis, a condition that causes muscle weakness. The goal was to see if the drug improves daily activities and is safe compared to a placebo. Participants received either the drug or a dummy…

This early-stage study tested a new cell therapy called MuSK-CAART in 7 people with a rare, severe form of myasthenia gravis (MuSK MG). The treatment uses a patient's own immune cells, modified to attack the harmful antibodies causing the disease. The main goal was to check safet…

This pilot study tested the drug tofacitinib in 19 adults with refractory myasthenia gravis, a condition where standard treatments fail. Participants took a 5 mg tablet twice daily for 4 months, followed by a 1-month washout. The study measured changes in muscle strength and dail…

This study looked at a device called GLOBAFFIN that filters antibodies from the blood to help people with autoimmune diseases. It involved 34 adults and measured how much harmful antibodies were removed and if patients felt better. The goal was to see if the device is safe and wo…

This study tested whether people with generalized myasthenia gravis could safely switch from intravenous (IV) infusions of complement inhibitors to daily injections of zilucoplan. Twenty-six participants who were stable on IV therapy switched to the subcutaneous shot. The main fo…

This study looked at whether having a tendency toward depression affects how well people with thymoma-associated myasthenia gravis (MG) respond to psychological counseling. Nineteen adults who had surgery for thymoma and MG received eight sessions of counseling based on Gestalt t…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study tested an online program to improve mental health in people with myasthenia gravis, a chronic muscle weakness condition. 77 patients completed a four-month program of short videos on Facebook about building social support, emotional awareness, and self-worth. Researche…

This study tested whether 62 people with generalized myasthenia gravis could learn to self-administer the drug rozanolixizumab at home using a syringe driver or manual push. Participants were trained and then assessed on their ability to correctly give themselves the infusion. Th…

This study tested whether acupuncture can improve quality of life and daily activities for people with myasthenia gravis, a condition that causes muscle weakness. Twenty-four adults received acupuncture twice a week for 12 weeks, with some starting immediately and others after a …

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study looked at how well two drugs, azathioprine and mycophenolate mofetil, work for people with myasthenia gravis in everyday medical practice. Researchers followed 82 adults with autoimmune MG for 2-3 years, measuring quality of life and side effects. The goal was to provi…

This completed study enrolled 311 people with myasthenia gravis, a condition that causes muscle weakness. Researchers collected clinical information and blood samples to build a repository for future studies. The goal is to help scientists better understand the disease and potent…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This completed study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and to understand what factors increase that risk. Researchers …

This completed study looked at how common cognitive (thinking) difficulties are in 150 people with myasthenia gravis. Researchers measured memory, attention, and other mental skills, and how these issues affect daily activities, work, and quality of life. The goal is to better un…

This study reviewed medical records of 100 people with myasthenia gravis who had thymus gland surgery. Researchers compared those with and without a thymus tumor to see what factors helped predict a full recovery. The goal was to better understand who benefits most from this proc…

This early-phase study tested the safety and tolerability of a new drug called LAD191 in 69 healthy adults and people with an autoimmune disease. Researchers gave single or multiple doses to see how the body processes the drug and if it causes side effects. The goal was to gather…

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This study tested a new sustained-release (long-acting) version of pyridostigmine, a drug used for myasthenia gravis (a muscle weakness disease). Forty healthy Chinese adults took both the new long-acting tablet and the standard immediate-release tablet at different times to comp…