Muscle tissue disorder
MONDO:0003939A disease involving the muscle tissue.
Also known as: disease of muscle organ, disease of muscle tissue, disease or disorder of muscle organ, disease or disorder of muscle tissue, disorder of muscle organ, disorder of muscle tissue, muscle organ disease, muscle organ disease or disorder
2419 clinical trials for this condition and its sub-types, 57 tagged with Muscle tissue disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Muscle tissue disorder
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Skeletal muscle disorder 10 trials · 1,363 incl. sub-types
13 sub-types
- Myopathy 15 trials · 987 incl. sub-types Sub-types →
- Hereditary skeletal muscle disorder 1 trial · 404 incl. sub-types Sub-types →
- Rotator cuff syndrome 272 trials
- Acquired skeletal muscle disease 0 trials · 166 incl. sub-types Sub-types →
- Diaphragm disorder 27 trials · 91 incl. sub-types Sub-types →
- Myotonic syndrome 11 trials · 61 incl. sub-types Sub-types →
- Anismus 12 trials
- Anterior compartment of tibia syndrome 1 trial
- Cyprus facial-neuromusculoskeletal syndrome 0 trials
- Tel Hashomer camptodactyly syndrome 0 trials
- Volkmann contracture 0 trials
- Muscular dystrophy-white matter spongiosis syndrome 0 trials
- Skeletal muscle neoplasm 0 trials Sub-types →
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Cardiomyopathy 155 trials · 819 incl. sub-types
12 sub-types
- Intrinsic cardiomyopathy 16 trials · 695 incl. sub-types Sub-types →
- Familial cardiomyopathy 2 trials · 217 incl. sub-types Sub-types →
- Tako-tsubo cardiomyopathy 16 trials
- Cardiomyopathy due to anthracyclines 16 trials
- Doxorubicin induced cardiomyopathy 7 trials
- Chagas cardiomyopathy 3 trials
- Extrinsic cardiomyopathy 3 trials Sub-types →
- Idiopathic cardiomyopathy 2 trials · 3 incl. sub-types Sub-types →
- Non-compaction cardiomyopathy 3 trials
- Keshan disease 0 trials
- Uhl anomaly 0 trials
- Autoimmune cardiomyopathy 0 trials Sub-types →
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Myomatous neoplasm 1 trial · 188 incl. sub-types
2 sub-types
- Smooth muscle tumor 2 trials · 187 incl. sub-types Sub-types →
- Benign muscle neoplasm 4 trials · 118 incl. sub-types Sub-types →
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Conduction system disorder 8 trials · 46 incl. sub-types
4 sub-types
- Sinoatrial node disorder 4 trials · 22 incl. sub-types Sub-types →
- Progressive familial heart block, type 1A 19 trials
- Atrioventricular node disorder 1 trial
- Atrial conduction disease 0 trials
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Myostatin-related muscle hypertrophy 10 trials
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Atrophic muscular disease 7 trials
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Distal arthrogryposis 0 trials · 3 incl. sub-types
23 sub-types
- Freeman-Sheldon syndrome 1 trial Sub-types →
- Congenital contractural arachnodactyly 1 trial
- Contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A 1 trial
- ACTC1-related distal arthrogryposis with congenital heart disease 0 trials
- Ehlers-Danlos syndrome, musculocontractural type 0 trials Sub-types →
- Gordon syndrome 0 trials
- Sheldon-hall syndrome 0 trials Sub-types →
- Arthrogryposis, distal, IIa 11 0 trials
- Arthrogryposis, distal, type 12 0 trials
- Arthrogryposis, distal, type 1C 0 trials
- Arthrogryposis, distal, type 2B4 0 trials
- Arthrogryposis, distal, type 2E 0 trials
- Arthrogryposis, distal, with impaired proprioception and touch 0 trials
- Arthrogryposis- oculomotor limitation-electroretinal anomalies syndrome 0 trials
- Arthrogryposis-ectodermal dysplasia-other anomalies syndrome 0 trials
- Arthrogryposis-like hand anomaly-sensorineural deafness syndrome 0 trials
- Arthrogryposis-severe scoliosis syndrome 0 trials
- Autism spectrum disorder - epilepsy - arthrogryposis syndrome 0 trials
- Digitotalar dysmorphism 0 trials Sub-types →
- Distal arthrogryposis Moore weaver type 0 trials
- Distal arthrogryposis type 10 0 trials
- Distal arthrogryposis type 5D 0 trials
- Trismus-pseudocamptodactyly syndrome 0 trials
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Kocher-debre-Semelaigne syndrome 0 trials
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Caveolinopathy 0 trials
1 sub-type
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Septal myocardial infarction 0 trials
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Striated muscle rhabdoid tumor 0 trials
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Tonsillar pillar cancer 0 trials
Most studied deeper sub-types
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Experimental drug AOC 1001 tested for Long-Term safety in rare muscle disease
Disease control CompletedThis study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…
Phase 2 • Sponsor: Avidity Biosciences, Inc. • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Dark chocolate compound may rescue muscle energy from statins
Disease control CompletedThis trial tests whether epicatechin, a compound naturally found in dark chocolate, can counteract the muscle-related side effects caused by statins, a common cholesterol-lowering medication. Participants with statin intolerance will receive epicatechin or a placebo, and research…
Sponsor: University of California, San Diego • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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New drug aims to help boys with duchenne walk longer
Disease control CompletedThis study tested a drug called ataluren in 360 boys with Duchenne muscular dystrophy caused by a specific genetic mistake (nonsense mutation). The main goal was to see if ataluren could help them walk farther over 72 weeks compared to a placebo. All participants were also taking…
Phase 3 • Sponsor: PTC Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New drug PGN-EDODM1 tested for muscle disease
Disease control CompletedThis early-stage trial tested a single dose of the drug PGN-EDODM1 in 24 adults with myotonic dystrophy type 1, a genetic muscle disorder. The main goal was to check safety and how the body handles the drug. The study is complete, but results are not yet available.
Phase 1 • Sponsor: PepGen Inc • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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New drug ABC008 shows promise in slowing rare muscle disease
Disease control CompletedThis study tested a new drug, ABC008, in 272 adults with inclusion body myositis, a rare muscle-weakening disease. The goal was to see if the drug is safe and can help slow the disease's progression. Participants received either ABC008 or a placebo, and their muscle function was …
Phase 2/3 • Sponsor: Abcuro, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New drug shows promise for rare energy disorder
Disease control CompletedThis study tested a new drug called OMT-28 in 28 people with primary mitochondrial disease, a condition that affects how cells produce energy. Participants took the drug once daily for 6 months, and researchers measured safety, blood markers of inflammation, and symptoms like fat…
Phase 2 • Sponsor: Omeicos Therapeutics GmbH • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Gene therapy zolgensma tested in kids with SMA who stopped other drugs
Disease control CompletedThis study tested a one-time gene therapy called OAV101 (Zolgensma) in 27 children aged 2 to 18 with spinal muscular atrophy (SMA) who had previously stopped taking other SMA medications (Spinraza or Evrysdi). The goal was to see if the treatment is safe and can help maintain or …
Phase 3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Gene therapy shows promise for kids with SMA type 2
Disease control CompletedThis study tested a one-time gene therapy called OAV101 in 126 children aged 2 to 18 with type 2 spinal muscular atrophy (SMA) who had never received other SMA treatments. The therapy was given as a spinal injection and compared to a sham procedure. The goal was to see if it coul…
Phase 3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:10 UTC
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Experimental drug shows promise for rare muscle diseases
Disease control CompletedThis study tested the long-term safety and effectiveness of a drug called KZR-616 in 18 adults with active polymyositis or dermatomyositis, rare diseases that cause muscle inflammation and weakness. Participants who completed an earlier study received weekly injections of KZR-616…
Phase 2 • Sponsor: Kezar Life Sciences, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Experimental drug KZR-616 tested for rare muscle disorders
Disease control CompletedThis Phase 2 trial tested a drug called KZR-616 (zetomipzomib) in 25 adults with active polymyositis or dermatomyositis, two rare diseases that cause muscle inflammation and weakness. Participants received either the drug or a placebo for 16 weeks, then switched to the other trea…
Phase 2 • Sponsor: Kezar Life Sciences, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Can a new workout boost balance in teens with movement disabilities?
Symptom relief CompletedThis study tests whether a new high-intensity exercise program is feasible and can improve dynamic balance and physical activity in adolescents with cerebral palsy or spina bifida. Participants will perform a series of exercises twice a week, with researchers measuring walking sp…
Sponsor: University of Alabama at Birmingham • Aim: Symptom relief
Last updated Aug 19, 2026 00:00 UTC
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Vibration or electrical stimulation: which better fights ICU muscle loss?
Symptom relief CompletedThis study tested two non-drug treatments—whole-body vibration and neuromuscular electrical stimulation—in 60 ICU patients with muscle weakness. Patients received one of the therapies twice daily for two weeks, alongside standard care. Researchers measured muscle strength and thi…
Sponsor: Cairo University • Aim: Symptom relief
Last updated Jul 26, 2026 00:00 UTC
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Robotic leg device shows promise for helping muscle disease patients walk
Symptom relief CompletedThis study tested a powered leg exoskeleton (Keeogo) in 50 people with various muscle disorders to see if it is safe and helps them walk better. Participants performed walking tests with and without the device. The goal was to see if the device could improve walking distance and …
Sponsor: Institut de Myologie, France • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Robotic exoskeleton shows promise for muscle disease patients
Symptom relief CompletedThis study tested a wearable robotic suit called MyoSuit that assists knee and hip movement in people with various muscle disorders. 32 participants used the device to perform walking tests, and researchers checked for safety and any immediate improvements in walking ability. The…
Sponsor: Institut de Myologie, France • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Could a High-Tech suit soothe fibromyalgia pain?
Symptom relief CompletedThis study tested whether a special suit called EXOPULSE Mollii can help adults with fibromyalgia feel less pain, fatigue, and depression. Twenty-eight participants wore either the active suit or a sham (fake) suit for two weeks, then had a washout period. After that, everyone co…
Sponsor: Sheikh Shakhbout Medical City • Aim: Symptom relief
Last updated Jun 26, 2026 15:18 UTC
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Real-World test gauges pain relief Devices' safety
Knowledge-focused CompletedThis study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…
Sponsor: DJO UK Ltd • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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Could a single workout shield damaged muscles? a new trial investigates
Knowledge-focused CompletedThis study explores whether a single bout of exercise can protect against muscle damage from a later session—a phenomenon called the repeated bout effect—in people with neuromuscular diseases. Unlike healthy individuals, patients with these conditions may experience muscle damage…
Sponsor: Mads Peter Godtfeldt Stemmerik • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Could a simple blood test predict statin muscle pain?
Knowledge-focused CompletedThis completed observational study from Latvia looked at whether statin-related muscle symptoms are linked to problems in fat metabolism in muscle cells. Researchers measured acylcarnitine levels in blood and muscle samples from 38 adults, comparing those with statin-related musc…
Sponsor: Riga Stradins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Ketone drink study reveals muscle secrets in aging men
Knowledge-focused CompletedThis study tested whether a ketone drink improves muscle function in 25 healthy men (12 young, 12 older). Participants drank a ketone monoester and underwent MRI scans, tracer infusions, and bike/dynamometer tests. Researchers compared results within and between age groups to see…
Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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New study aims to uncover why some myotonic dystrophy patients develop low breathing
Knowledge-focused CompletedThis study followed 113 adults with myotonic dystrophy (Steinert's disease) for 5 years to find out what factors lead to low breathing (hypoventilation). Researchers measured lung function, sleepiness, fatigue, and thinking skills. The goal is to better understand which patients …
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC