Mineral metabolism disease

This study investigates whether giving phosphate through an IV can reduce the severity of acute pancreatitis in adults. Researchers want to know if low phosphate levels make the disease worse and if replenishing it helps. Participants receive either standard care or IV phosphate …

This study tests a new drug called EPN-701 for calciphylaxis, a rare condition causing painful skin sores with no approved treatment. About 60 adults with moderate to severe pain and at least one open sore will receive the drug. The main goals are to see if EPN-701 safely reduces…

This study tests whether a wearable goggle system that makes parathyroid glands glow can help surgeons find and protect them during thyroid removal. About 280 adults having thyroid surgery will take part. The goal is to reduce the risk of low calcium levels after surgery, a commo…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests a device that uses sound waves (lithotripsy) to break up calcium buildup in the carotid arteries—the main arteries in the neck—before placing a stent to keep them open. The goal is to see if this approach reduces complications like stroke, heart attack, or death …

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in the carotid arteries of the neck before placing a stent. About 185 people with heavily calcified carotid arteries will be enrolled. The main goal is to see if the procedure is s…

This study compares two methods to treat severely calcified coronary arteries: one uses a special balloon that inflates at very high pressure, and the other combines a rotating burr with sound waves to break up calcium. Researchers will enroll 162 adults with hardened arteries to…

This study tests whether a citrate-based dialysis fluid with extra magnesium can slow or prevent blood vessel hardening in adults on long-term hemodialysis. Eighty stable patients will receive either the new fluid or a standard one for 12 months. Researchers will measure blood ma…

This phase III trial tests a vitamin B12 injection (hydroxocobalamin chloride) in 20 children aged 6 months to 18 years with a specific type of methylmalonic acidemia (cobalamin C deficiency). The goal is to see if the injection can normalize levels of certain acids in the blood …

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This study will use ultrasound to check for medial arterial calcification (hardening of the arteries) in 60 healthy endurance athletes. The goal is to find out how common this condition is in this group and see if it relates to their training habits or heart risk factors. Partici…

This study will compare two standard approaches for replacing phosphate in critically ill patients in the intensive care unit (ICU). One approach starts replacement at a higher phosphate level (liberal), the other at a lower level (restrictive). The goal is to see if the restrict…

This study looks at whether having one or two faulty copies of the CYP24A1 gene makes kidney stones more likely. Researchers will compare people with different gene variants to see how often stones occur. The goal is to better understand the genetic factors behind this common and…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study will translate and test two questionnaires (HPES-Symptom and HPES-Impact) for Greek-speaking adults with chronic hypoparathyroidism. Researchers will enroll 200 patients across several hospitals in Greece. The goal is to ensure the questionnaires accurately capture pat…

This study looks at how age and sex influence the body's ability to manage phosphate after a single oral dose. Forty healthy volunteers in two age groups (18-25 and 63-70) will ingest 558 mg of phosphorus, and researchers will measure phosphate levels in the blood over time. The …