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A blood marker may warn of dangerous metabolic shifts in the ICU

NCT ID NCT07800143

Knowledge-focused Sponsor: Vastra Gotaland Region Source: ClinicalTrials.gov ↗

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Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
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Paused for now. It may or may not start again.
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The trial has finished. Results may not be published yet.
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Cancelled before anyone took part.

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This study investigates whether changes in serum phosphate, a blood electrolyte, are linked to respiratory quotient, a measure of how the body uses energy, in critically ill patients during their first week in intensive care. The goal is to see if a rising respiratory quotient could serve as an early indicator of refeeding syndrome, a potentially serious condition that can occur when nutrition is started after a period of low intake. Researchers will monitor 40 mechanically ventilated adults using daily indirect calorimetry and blood tests, without changing their standard care. The study also checks how well existing screening criteria identify patients at risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
No intervention is assigned. The study observes standard nutritional care and metabolic measurements in critically ill patients.
What this could lead to
If successful, this could lead to a simple early warning sign for refeeding syndrome, helping doctors adjust nutrition to prevent complications in intensive care patients.
What could go wrong
This is a small observational study, so it cannot prove cause and effect. The findings may not apply to all patients, and the proposed marker may not be reliable enough for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients admitted to the central intensive care unit (CIVA) or neurointensive care unit (NIVA) at Sahlgrenska University Hospital who are receiving invasive mechanical ventilation, have an expected ICU stay of more than 72 hours, and have enteral or parenteral nutrition started or planned. Eligible patients are identified prospectively during routine daily ICU screening and included according to predefined inclusion and exclusion criteria.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older. * Admitted to the central intensive care unit (CIVA) or neurointensive care unit (NIVA) at Sahlgrenska University Hospital. * Receiving invasive mechanical ventilation. * Expected intensive care stay longer than 72 hours. * Enteral or parenteral nutritional therapy started or planned. * Arterial catheter in place for clinically indicated blood sampling. * Participation considered clinically safe by the responsible physician and research nurse. Exclusion Criteria: * Ongoing or planned continuous renal replacement therapy or intermittent - hemodialysis (CRRT/iHD). * Extracorporeal membrane oxygenation (ECMO). * Fraction of inspired oxygen (FiO2) \>0.70. * Severe renal failure or rapidly increasing creatinine without dialysis, where phosphate levels may not adequately reflect metabolic changes. * Terminal illness or decision for end-of-life care. * Previous participation in the study during the same ICU admission.

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Conditions

The condition(s) this trial relates to.

Critical Illness hypophosphatemia refeeding syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Metabolic changes during critical illness Refeeding syndrome

How to take part

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  1. The official record

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