Migraine with aura

This trial tests whether rimegepant, a newer migraine medication, works as well as flunarizine, an older preventive, for reducing days with moderate-to-severe dizziness in people with vestibular migraine. About 400 adults aged 18 to 75 will take one of the two drugs daily for 12 …

This study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…

This study will test two FDA-approved migraine drugs, rimegepant (a tablet that dissolves on the tongue) and zavegepant (a nasal spray), in 100 adults visiting the emergency department for a migraine. The goal is to see if these drugs provide pain relief within 2 hours without ne…

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study compares a combination of two drugs (dexamethasone and metoclopramide) against standard painkillers (paracetamol or NSAIDs) for treating severe primary headaches in the emergency department. 94 adults aged 18-60 with a pain score of 5 or higher will be randomly assigne…

This study tests whether using a virtual reality headset to practice a type of mindfulness therapy called Acceptance and Commitment Therapy (ACT) can reduce migraine-related disability. About 160 adults with episodic migraine will either continue their usual care or add VR sessio…

This early-phase trial at Boston Children's Hospital will test whether adding virtual reality (VR) to standard treatments like biofeedback and cognitive behavioral therapy can help 12 adolescents with chronic dizziness. The goal is to see if VR can safely and feasibly reduce dizz…

This study will test whether a smartphone app called Health enSuite Migraine can help people aged 18 to 50 reduce how often they get migraine headaches. The app teaches simple techniques like managing triggers, relaxing, and changing negative thoughts. About 415 Canadian adults w…

This pilot study tests a new, non-drug treatment for vestibular migraine, a condition causing repeated dizziness and headaches. Fifty adults will receive either real or sham electrical stimulation behind the ears over six sessions. The main goal is to see if the treatment is safe…

This study will test CGRP-targeted medications in 2,000 Chinese adults with vestibular migraine, a condition causing severe vertigo and dizziness. The goal is to see if these drugs can reduce the severity and frequency of attacks, both as immediate treatment and for prevention. P…

This study aims to validate a questionnaire called VM-PATHI for adolescents aged 10-20 with vestibular migraine, a condition causing dizziness and other symptoms. Researchers will test whether the tool accurately measures symptom severity and meaningful improvement. About 70 part…

This study compares uric acid levels in 80 adolescents (12-18 years) with and without primary headaches. Researchers aim to see if there is a link between uric acid and headaches, which could help understand what causes them. Participants will provide a blood sample and have thei…

This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…

This study will give 21 people with migraine with aura an infusion of a protein called PACAP-38, or a placebo, to see if it can trigger an aura attack. The goal is to better understand what causes migraine aura, not to test a treatment. Participants will be monitored for 12 hours…