Intellectual disability

This pilot trial tests whether a digital inhaler cap, which gives real-time guidance on inhaler technique, can help adolescents with intellectual and developmental disabilities (IDD) manage their asthma at home. The study will compare active use of the smart inhaler to passive us…

This study tests a custom-made drug called an antisense oligonucleotide (ASO) designed for one person with Schuurs-Hoeijmakers syndrome, a rare genetic condition. The drug aims to correct a specific genetic mutation to improve communication and motor skills. Only one participant …

This study will test whether using remote monitoring (like video calls or apps) to manage orthodontic aligner treatment works as well as traditional in-person visits for children aged 11-12 with mild intellectual disability. The main goal is to see if kids stick to their treatmen…

This study tests whether combining several advanced genetic analysis techniques can find the cause of intellectual disability or neurodevelopmental disorders in people who have already had standard genetic testing with no answer. Participants will have their existing genetic data…

This study tests whether a simple saliva swab can find genetic causes of neurodevelopmental or intellectual disorders when standard blood tests have not. Researchers will use advanced DNA sequencing on cheek cells from 50 participants. The goal is to improve diagnosis and help gu…

This study tests whether sending text messages or voice call reminders with helpful behavior change tips can improve how many babies get their full set of vaccines on time. About 7,800 caregivers of newborns in Bangladesh will be split into three groups: one gets no reminders, on…

This study tests whether short, frequent bursts of exercise—called exercise snacks—can improve cognitive function and physical health in adults with mild to moderate intellectual disability. Participants will try three approaches: exercise snacks, a single session of high-intensi…

This pilot study tests a therapy protocol based on cognitive-occupational principles (CO-OP) for children and adolescents aged 10-21 with mild to moderate intellectual disability. The intervention involves weekly 45-minute sessions over 12-15 weeks, delivered by occupational ther…

This early-stage trial will test whether higher-than-standard doses of memantine, a drug already approved for Alzheimer's, are safe and tolerable in 25 adolescents and young adults with Down syndrome. The study also looks for early signs that the drug might improve memory and thi…

This study tests whether electroacupuncture (mild electrical pulses through thin needles) can help patients whose stomachs stop working properly after surgery for digestive tract tumors. Seventy-six adults who had such surgery and developed gastroparesis (stomach paralysis) will …

This study will test a new occupational therapy program in schools for children aged 6 to 14 with Autism Spectrum Disorder or Intellectual Disability. The program focuses on improving sensory processing and daily living skills through weekly 50-minute sessions over 10 to 12 weeks…

This study will test whether weekly gardening activities can improve the quality of life for 30 secondary school students with mild intellectual disabilities. For 8 weeks, students will spend about 40 minutes each week planting and caring for plants in a school greenhouse. Resear…

This study tests whether wearing a virtual reality headset during a dental cleaning can reduce pain in children aged 5 to 7 with mild intellectual disability and moderate dental anxiety. Half of the 102 participants will use VR while the other half receives standard care. Pain le…

This study tests whether wearing virtual reality goggles during a dental cleaning can reduce how much pain children with mild intellectual disability feel. About 102 children aged 5 to 7 with moderate dental anxiety will take part. Half will use VR during cleaning, and half will …

This study looks at whether a therapy called Acceptance and Commitment Therapy (ACT) can help fathers of children with special needs feel more flexible in their thinking and improve their mental health. About 50 fathers will take part, with half getting ACT and the other half rec…

This pilot study will test whether a program called Facing Your Fears can help reduce anxiety in 24 children aged 12-18 who have both autism spectrum disorder and intellectual disability. The program uses cognitive behavioral therapy techniques like gradual exposure to feared sit…

This study tests whether adding a health education and coaching program to Special Olympics activities helps adults with intellectual or developmental disabilities get better healthcare. About 1,040 athletes and their care partners will take part. The goal is to see if this extra…

This study aims to create a therapy program using Acceptance and Commitment Therapy (ACT) for fathers of children with special needs in Hong Kong. Researchers will interview 20 fathers and social workers to understand their challenges and what kind of support would help. The goal…

This study looks at whether young adults (ages 18-27) with mild to moderate intellectual or developmental disabilities feel less lonely and more connected when they learn travel skills from a peer who also has a disability, compared to learning from regular staff. About 325 parti…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This pilot study will test if a friendly robot named Pepper can help 25 adults with intellectual disabilities learn about breast and colorectal cancer. The robot will deliver interactive lessons and quizzes. The goal is to see if this approach boosts cancer knowledge and reduces …

This study looks at how people with mild intellectual disability process emotions compared to those with autism and typically developing individuals. It also tests a special therapy program to help them regulate emotions. 40 people with intellectual disability will take part in t…

This study tests a new DNA sequencing method that reads long stretches of DNA to find hidden genetic changes causing rare diseases like albinism and intellectual disability. Researchers will analyze stored blood or DNA from 150 patients who haven't gotten a clear diagnosis yet. T…

This study looks at whether adding decoding and encoding practice to the ALLSTAR literacy program helps children with complex communication needs learn to read better. Sixty children aged 5-12 who use augmentative and alternative communication (AAC) will be split into two groups:…

This study will follow 900 Spanish adults with intellectual disabilities for one year to understand why they fall. Researchers will check medical records, balance, and walking ability. The goal is to create a tool that can predict who is at risk of falling, so caregivers can take…